Evidence map›Paper›PMID 32687975›Full record

ReviewTranslational research : the journal of laboratory and clinical medicine2020

Microbiota reprogramming for treatment of alcohol-related liver disease.

Mohamed Tausif Siddiqui, Gail A M Cresci

Open access · greenAbstract readReview
In one paragraph

Review in Translational research : the journal of laboratory and clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Symbiotic combination ofFrontiers in microbiology · 2024
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mohamed Tausif SiddiquiCenter for Human Nutrition, Cleveland Clinic, Cleveland, Ohio; Department of Inflammation & Immunity, Cleveland Clinic, Cleveland, Ohio.
Gail A M CresciCenter for Human Nutrition, Cleveland Clinic, Cleveland, Ohio; Department of Inflammation & Immunity, Cleveland Clinic, Cleveland, Ohio; Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, Ohio. Electronic address: crescig@ccf.org.
Cleveland Clinic · US

Funding

Combined Training Program in Digestive Disease SciencesT32DK083251 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI COMINELLI, FABIO, FIOCCHI, CLAUDIO · 2010 to 2025
$3.6M
Targeting ethanol-induced gut dysbiosis with synbiotics to treat alcoholic liverR00AA023266 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI CRESCI, GAIL ANN · 2017 to 2019
$747k
NIAAA NIH HHS R00 AA023266NIDDK NIH HHS T32 DK083251
6 · The paper itself

Abstract

In the past decade knowledge has expanded regarding the importance of the gut microbiota in maintaining intestinal homeostasis and overall health. During this same time, we have also gained appreciation for the role of the gut-liver axis in the development of liver diseases. Alcohol overconsumption is one of the leading causes of liver failure globally. However, not all people with alcohol use disorder progress to advanced stages of liver disease. With advances in technology to investigate the gut microbiome and metabolome, we are now beginning to delineate alcohol's effects on the gut microbiome in relation to liver disease. This review presents our current understanding on the role of the gut microbiota during alcohol exposure, and various therapeutic attempts that have been made to reprogram the gut microbiota with the goal of alleviating alcoholic-related liver disease.

Indexed as

Gastrointestinal MicrobiomeAnimalsDisease Models, AnimalFecal Microbiota TransplantationHumansLiver Diseases, AlcoholicProbiotics

Identifiers

PMID32687975
PMCPMC7572584
OpenAlexW3042612584

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.