Evidence mapPaperPMID 32693765Full record

ReviewCurrent pharmaceutical design2020

Cellular and Functional Effects of Insulin Based Therapies and Exercise on Endothelium.

Melissa A Luse, Emily M Heiston, Steven K Malin, Brant E Isakson

Open access · greenAbstract readReview
In one paragraph

Review in Current pharmaceutical design, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Issues on Trainability.Frontiers in physiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Melissa A LuseRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Virginia, United States.
Emily M HeistonRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Virginia, United States.
Steven K MalinRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Virginia, United States.
Brant E IsaksonRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Virginia, United States.
University of Virginia · US

Funding

BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · 1985 to 2025
$5.4M
NHLBI NIH HHS R01 HL088554NHLBI NIH HHS T32 HL007284
6 · The paper itself

Abstract

Endothelial dysfunction is a hallmark of type 2 diabetes that can have severe consequences on vascular function, including hypertension and changes in blood flow, as well as exercise performance. Because endothelium is also the barrier for insulin movement into tissues, it acts as a gatekeeper for transport and glucose uptake. For this reason, endothelial dysfunction is a tempting area for pharmacological and/or exercise intervention with insulin-based therapies. In this review, we describe the current state of drugs that can be used to treat endothelial dysfunction in type 2 diabetes and diabetes-related diseases (e.g., obesity) at the molecular levels, and also discuss their role in exercise.

Indexed as

Diabetes Mellitus, Type 2Insulin ResistanceEndothelium, VascularExerciseHumansInsulinInsulinEndothelial dysfunctionexercisehypertensioninsulinpharmacologicalvascular function

Identifiers

PMID32693765
PMCPMC8011202
OpenAlexW3044384545

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.