Evidence map›Paper›PMID 32694673›Full record

ArticleNature metabolism2019

Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss.

Emily A Day, Rebecca J Ford, Brennan K Smith, Pedrum Mohammadi-Shemirani, Marisa R Morrow, Robert M Gutgesell, Rachel Lu, Amogelang R Raphenya, Mostafa Kabiri, Andrew G McArthur and 5 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Nature metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07244575 (Association Between Preoperative Metformin Exposure and Postoperative Nausea and Vomiting in Patients Undergoing General Anesthesia), which is not on this map. Cited by 151 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed, 1 pooled it
24.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07244575 recruitingnot on this mapstarted 2025, after this paper: background citation

Association Between Preoperative Metformin Exposure and Postoperative Nausea and Vomiting in Patients Undergoing General Anesthesia: a Prospective Observational Cohort Study

TypeobservationalSponsorSixth Affiliated Hospital, Sun Yat-sen UniversityRan2025 to 2033Enrolled909ConditionsPostoperative Nausea and Vomiting
3 · Its place in the literature

Who cites it

151 citing papers in PubMed, 1 synthesis or guideline pooled it, 291 citations in OpenAlex.

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  20. GDF15 in aging, metabolic disease and cachexia.The journal of nutrition, health & aging · 2026
    Article

91 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Emily A Day *Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
Rebecca J Ford *Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
Brennan K SmithCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
Pedrum Mohammadi-ShemiraniPopulation Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.
Marisa R MorrowCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
Robert M GutgesellCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
Rachel LuCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
Amogelang R RaphenyaDepartment of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0001-9259-5280
Mostafa KabiriSanofi Aventis Deutschland, Translational in vivo Models, Sanofi Research and Development, Frankfurt, Germany.
Andrew G McArthurCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
Natalia McInnesCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
Sibylle HessSanofi Aventis Deutschland GmbH, Research and Development Division, Translational Medicine and Early Development, Biomarkers and Clinical Bioanalyses, Frankfurt, Germany.
Guillaume ParéCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
Hertzel C GersteinCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada.
Gregory R SteinbergCentre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada. gsteinberg@mcmaster.ca.ORCID http://orcid.org/0000-0001-5425-8275
McMaster University · CAPopulation Health Research Institute · CASanofi (Germany) · DEMcMaster University Medical Centre · CA

Funding

CIHR 201709FDN-CEBA-116200
6 · The paper itself

Abstract

Metformin is the most commonly prescribed medication for type 2 diabetes, owing to its glucose-lowering effects, which are mediated through the suppression of hepatic glucose production (reviewed in refs.

Indexed as

AnimalsAppetite DepressantsBody WeightDiabetes Mellitus, Type 2Diet, High-FatEatingGlucose IntoleranceGrowth Differentiation Factor 15HepatocytesHumansHypoglycemic AgentsInsulinMaleMetforminMicePrimary Cell CultureAppetite DepressantsGdf15 protein, mouseGrowth Differentiation Factor 15Hypoglycemic AgentsInsulinMetformin

Identifiers

PMID32694673
OpenAlexW2992288250

What Socratic holds

Texttitle and abstract
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.