Evidence map›Paper›PMID 32696219›Full record

ArticleGeroScience2020

Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats.

Shaoxun Wang, Wenshan Lv, Huawei Zhang, Yedan Liu, Longyang Li, Joshua R Jefferson, Ya Guo, Man Li, Wenjun Gao, Xing Fang and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 2 countries.

Shaoxun WangDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Wenshan LvDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Huawei ZhangDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Yedan LiuDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Longyang LiDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Joshua R JeffersonDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Ya GuoDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Man LiDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Wenjun GaoDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Xing FangDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Ian A PaulDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
Grazyna RajkowskaDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
James P ShafferyDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
Thomas H MosleyDepartment of Neurology, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
Xinlin HuDepartment of Endocrinology and Metabolic, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, China.
Ruen LiuDepartment of Neurosurgery, Peking University People's Hospital, Beijing, 100044, China.
Yangang WangDepartment of Endocrinology and Metabolic, The Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong, China.
Hongwei YuDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Richard J RomanDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Fan FanDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA. ffan@umc.edu.ORCID 0000-0003-1463-3610
State Street (United States) · USQingdao University · CNUniversity of Mississippi Medical Center · USJackson Memorial Hospital · USMedical College of Wisconsin · USPeking University · CN

Funding

Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Jane F Reckelhoff · 2017 to 2026
$26.4M
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4M
Genetic determinants of hypertension-induced cerebral vascular dysfunctionR01HL138685 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROMAN, RICHARD J. · 2018 to 2021
$1.9M
Adducin, actin cytoskeleton and cognitive impairmentsR01AG057842 · NIA · UNIVERSITY OF MISSISSIPPI MED CTR · PI WILLIAMS, JAN MICHAEL · 2019 to 2023
$1.9M
Renal microcirculation and hypertension induced renal injuryR01DK104184 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROMAN, RICHARD J. · 2014 to 2017
$1.8M
Animal model of impaired autoregulation for study of age related vascular cognitive impairmentR21AG050049 · NIA · UNIVERSITY OF MISSISSIPPI MED CTR · PI FAN, FAN · 2016 to 2017
$419k
NHLBI NIH HHS R01 HL138685NIA NIH HHS R01 AG057842NIA NIH HHS R21 AG050049NIDDK NIH HHS R01 DK104184NIGMS NIH HHS P20 GM104357NIGMS NIH HHS P20 GM121334NIH HHS 16GRNT31200036
6 · The paper itself

Abstract

Diabetes mellitus (DM) is a leading risk factor for aging-related dementia; however, the underlying mechanisms are not well understood. The present study, utilizing a non-obese T2DN diabetic model, demonstrates that the myogenic response of the middle cerebral artery (MCA) and parenchymal arteriole (PA) and autoregulation of cerebral blood flow (CBF) in the surface and deep cortex were impaired at both young and old ages. The impaired CBF autoregulation was more severe in old than young DM rats, and in the deep than the surface cortex. The myogenic tone of the MCA was enhanced at perfusion pressure in the range of 40-100 mmHg in young DM rats but was reduced at 140-180 mmHg in old DM rats. No change of the myogenic tone of the PA was observed in young DM rats, whereas it was significantly reduced at 30-60 mmHg in old DM rats. Old DM rats had enhanced blood-brain barrier (BBB) leakage and neurodegeneration, reduced vascular density, tight junction, and pericyte coverage on cerebral capillaries in the CA3 region in the hippocampus. Additionally, DM rats displayed impaired functional hyperemia and spatial learning and short- and long-term memory at both young and old ages. Old DM rats had impaired non-spatial short-term memory. These results revealed that impaired CBF autoregulation and enhanced BBB leakage plays an essential role in the pathogenesis of age- and diabetes-related dementia. These findings will lay the foundations for the discovery of anti-diabetic therapies targeting restoring CBF autoregulation to prevent the onset and progression of dementia in elderly DM.

Indexed as

Diabetes Mellitus, ExperimentalAgingAnimalsCerebrovascular CirculationCognitionHomeostasisRatsAutoregulationBlood-brain barrierCognitive impairmentsDiabetes mellitusMyogenic response

Identifiers

PMID32696219
PMCPMC7525432
OpenAlexW3045398999

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.