Evidence map›Paper›PMID 32697195›Full record

ArticleeLife2020

Genetic and environmental determinants of variation in the plasma lipidome of older Australian twins.

Matthew Wk Wong, Anbupalam Thalamuthu, Nady Braidy, Karen A Mather, Yue Liu, Liliana Ciobanu, Bernhardt T Baune, Nicola J Armstrong, John Kwok, Peter Schofield and 6 more

Open access · goldAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Biomedicines · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. The Genetic Basis of Hypertriglyceridemia.Current atherosclerosis reports · 2021
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Matthew Wk WongCentre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia.ORCID 0000-0001-6913-4558
Anbupalam ThalamuthuCentre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia.
Nady BraidyCentre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia.
Karen A MatherCentre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia.
Yue LiuCentre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia.
Liliana CiobanuCentre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia.
Bernhardt T BauneThe University of Adelaide, Adelaide Medical School, Discipline of Psychiatry, Adelaide, Australia.
Nicola J ArmstrongMathematics and Statistics, Murdoch University, Perth, Australia.ORCID 0000-0002-4477-293X
John KwokBrain and Mind Centre, The University of Sydney, Sydney, Australia.
Peter SchofieldNeuroscience Research Australia, Sydney, Australia.
Margaret J WrightQueensland Brain Institute, University of Queensland, Brisbane, Australia.ORCID 0000-0001-7133-4970
David AmesUniversity of Melbourne Academic Unit for Psychiatry of Old Age, Kew, Australia.
Russell PickfordBioanalytical Mass Spectrometry Facility, University of New South Wales, Sydney, Australia.
Teresa LeeCentre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia.
Anne Poljak *Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia.
Perminder S Sachdev *Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia.ORCID 0000-0002-9595-3220
UNSW Sydney · AUThe University of Melbourne · AUMurdoch University · AUSouth Australia Pathology · AUThe University of Queensland · AUThe University of Sydney · AU

Funding

National Health and Medical Research Council 1045325National Health and Medical Research Council 1085606
6 · The paper itself

Abstract

The critical role of blood lipids in a broad range of health and disease states is well recognised but less explored is the interplay of genetics and environment within the broader blood lipidome. We examined heritability of the plasma lipidome among healthy older-aged twins (75 monozygotic/55 dizygotic pairs) enrolled in the Older Australian Twins Study (OATS) and explored corresponding gene expression and DNA methylation associations. 27/209 lipids (13.3%) detected by liquid chromatography-coupled mass spectrometry (LC-MS) were significantly heritable under the classical ACE twin model (h

Indexed as

Gene-Environment InteractionAgedAged, 80 and overAgingCpG IslandsDNA MethylationFemaleGene ExpressionGenome, HumanHumansInheritance PatternsLipidomicsLipidsMalePhenotypeTwinsLipidschromosomesgene expressiongeneticsgenomicsheritabilityhumanlipidomics

Identifiers

PMID32697195
PMCPMC7394543
OpenAlexW3044213557

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.