Evidence map›Paper›PMID 32699180›Full record

Trial reportJournal of investigative medicine : the official publication of the American Federation for Clinical Research2020

Dietary sodium restriction decreases urinary NGAL in older adults with moderately elevated systolic blood pressure free from chronic kidney disease.

Wei Wang, Michel Chonchol, Douglas R Seals, Kristen L Nowak

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Wei WangDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Michel ChoncholDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Douglas R SealsDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado, USA.
Kristen L NowakDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA Kristen.Nowak@cuanschutz.edu.ORCID 0000-0001-9364-3256
University of Colorado Anschutz Medical Campus · USUniversity of Colorado Boulder · US

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Weight Loss, Inflammation, and Vascular Endothelial Function in Older AdultsR01AG006537 · NIA · UNIVERSITY OF COLORADO AT BOULDER · PI SEALS, DOUGLAS R · 1986 to 2010
$4.4M
SODIUM RESTRICTION &ARTERIAL COMPLIANCE IN OLDER HUMANSR01AG013038 · NIA · UNIVERSITY OF COLORADO AT BOULDER · PI SEALS, DOUGLAS R · 1996 to 2018
$4.0M
Human Aging, Exercise &FMD: Translational PhysiologyR37AG013038 · NIA · UNIVERSITY OF COLORADO AT BOULDER · PI SEALS, DOUGLAS R · 2004 to 2013
$3.0M
Reduced Inflammatory Suppression of EDD with Habitual Exercise in Older AdultsR01AG031141 · NIA · UNIVERSITY OF COLORADO · PI SEALS, DOUGLAS R · 2008 to 2010
$1.5M
Inflammatory suppression of endothelial function with aging and habitual exerciseF31AG031617 · NIA · UNIVERSITY OF COLORADO · PI WALKER, ASHLEY ELIZABETH · 2007 to 2010
$65k
Vascular Endothelial Dysfunction in Older Adults: Dietary Sodium RestrictionF31AG033994 · NIA · UNIVERSITY OF COLORADO · PI NOWAK, KRISTEN LYNN · 2009 to 2010
$59k
NCATS NIH HHS UL1 TR002535NIA NIH HHS F31 AG031617NIA NIH HHS F31 AG033994NIA NIH HHS R01 AG006537NIA NIH HHS R01 AG013038NIA NIH HHS R01 AG031141NIA NIH HHS R37 AG013038
6 · The paper itself

Abstract

Increased aortic stiffness may contribute to kidney damage by transferring excessive flow pulsatility to susceptible renal microvasculature, leading to constriction or vessel loss. We previously demonstrated that 5 weeks of dietary sodium restriction (DSR) reduces large-elastic artery stiffness as well as blood pressure in healthy middle-aged/older adults with moderately elevated systolic blood pressure (SBP) who are free from chronic kidney disease (CKD). We hypothesized that DSR in this cohort would also reduce urinary concentrations of renal tubular injury biomarkers, which predict incident CKD in the general population. We performed a post hoc analysis using stored 24 hours urine samples collected in 13 participants as part of a randomized, double-blind, crossover clinical trial of DSR (low sodium (LS) target: 50 mmol/day; normal sodium (NS) target: 150 mmol/day). Participants were 61±2 (mean±SEM) years (8 M/5 F) with a baseline blood pressure of 139±2/82±2 mm Hg and an estimated glomerular filtration rate of 79±3 mL/min/1.73 m

Indexed as

Blood PressureDiet, Sodium-RestrictedLipocalin-2Renal Insufficiency, ChronicSystoleAgedFemaleHepatitis A Virus Cellular Receptor 1HumansMaleMiddle AgedHAVCR1 protein, humanHepatitis A Virus Cellular Receptor 1LCN2 protein, humanLipocalin-2hypertensionkidneysodiumvascular stiffness

Identifiers

PMID32699180
PMCPMC7531580
OpenAlexW3044047862

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.