Evidence map›Paper›PMID 32700809›Full record

SynthesisESC heart failure2020

A comprehensive individual patient data meta-analysis of the effects of cardiac contractility modulation on functional capacity and heart failure-related quality of life.

Francesco Giallauria, Gianluigi Cuomo, Alessandro Parlato, Nirav Y Raval, Jürgen Kuschyk, Andrew Js Stewart Coats

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in ESC heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Francesco GiallauriaDepartment of Translational Medical Sciences, "Federico II" University of Naples, Via S. Pansini 5, Naples, 80131, Italy.
Gianluigi CuomoDepartment of Translational Medical Sciences, "Federico II" University of Naples, Via S. Pansini 5, Naples, 80131, Italy.
Alessandro ParlatoDepartment of Translational Medical Sciences, "Federico II" University of Naples, Via S. Pansini 5, Naples, 80131, Italy.
Nirav Y RavalAdvent Health Transplant Institute, Orlando, FL, USA.
Jürgen KuschykI. Medical Department, University Medical Centre, Mannheim, Germany.
Andrew Js Stewart CoatsIRCCS San Raffaele Pisana, Rome, Italy.
Federico II University Hospital · ITFlorida Hospital Cancer Institute · USIRCCS Ospedale San Raffaele · ITUniversity Medical Centre Mannheim · DEUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsCardiac contractility modulation, also referred to as CCM™, has emerged as a promising device treatment for heart failure (HF) in patients not indicated for cardiac resynchronization therapy. We performed a comprehensive individual patient data meta-analysis of all non-confounded prospective randomized controlled trials of CCM vs. control that have measured functional capacity and/or quality of life questionnaires in patients with HF. METHODS AND

resultsThe Cochrane Central Register of Controlled Trials, MEDLINE, and EMBASE were searched in January 2020 to identify eligible randomized controlled trials. We also asked the sole manufacturer of the device for their list of known trials. Primary outcomes of interest were peak oxygen consumption (peak VO

conclusionsThis comprehensive meta-analysis of individual patient data from all known randomized trials has shown that CCM provides statistically significant and clinically meaningful benefits in measures of functional capacity and HF-related quality of life.

Indexed as

Heart FailureQuality of LifeHumansMyocardial ContractionProspective StudiesRandomized Controlled Trials as TopicTreatment Outcome6 min walk testCardiac contractility modulationIndividual patient data meta-analysisMinnesota Living with Heart Failure QuestionnaireOPTIMIZER™ devicePeak oxygen consumption

Identifiers

PMID32700809
PMCPMC7524137
OpenAlexW3045473821

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.