Evidence map›Paper›PMID 32703204›Full record

ReviewMalaria journal2020

Pathophysiology and neurologic sequelae of cerebral malaria.

Nicoline Schiess, Andres Villabona-Rueda, Karissa E Cottier, Katherine Huether, James Chipeta, Monique F Stins

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Malaria journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 2 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.

  1. Spectrum of movement disorders in Malaria: a systematic review of case reports, case series, and cohort studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  11. Malaria signs, symptoms, prevention knowledge and its associated factors among rural Ethiopians.African journal of primary health care & family medicine · 2025
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Nicoline SchiessDepartment of Neurology, Johns Hopkins School of Medicine, 600 N. Wolfe St., Meyer 6-113, Baltimore, MD, 21287, USA.
Andres Villabona-RuedaMalaria Research Institute, Dept Molecular Microbiology Immunology, Johns Hopkins School of Public Health, 615 N Wolfe Street, Baltimore, MD, 21205, USA.
Karissa E CottierMalaria Research Institute, Dept Molecular Microbiology Immunology, Johns Hopkins School of Public Health, 615 N Wolfe Street, Baltimore, MD, 21205, USA.
Katherine HuetherJohns Hopkins School of Medicine, Baltimore, MD, 21287, USA.
James ChipetaDepartment of Paediatrics, University Teaching Hospital, Nationalist Road, Lusaka, Zambia.
Monique F StinsMalaria Research Institute, Dept Molecular Microbiology Immunology, Johns Hopkins School of Public Health, 615 N Wolfe Street, Baltimore, MD, 21205, USA. mstins@jhmi.edu.ORCID http://orcid.org/0000-0002-8559-5626
Johns Hopkins University · USUniversity of Mary · USUniversity Teaching Hospital · ZM

Funding

Brain vascular dysfunction in cerebral malariaR01HL130649 · NHLBI · LA JOLLA INFECTIOUS DISEASE INSTITUTE · PI JACOBS-LORENA, MARCELO, STINS, MONIQUE F · 2015 to 2018
$2.0M
Role of the blood brain barrier in neurologic sequelaeR03NS087303 · NINDS · JOHNS HOPKINS UNIVERSITY · PI STINS, MONIQUE F · 2014 to 2015
$178k
NHLBI NIH HHS R01 HL130649NIH HHS HL130649NIH HHS NS087303-02NINDS NIH HHS R03 NS087303
6 · The paper itself

Abstract

Cerebral malaria (CM), results from Plasmodium falciparum infection, and has a high mortality rate. CM survivors can retain life-long post CM sequelae, including seizures and neurocognitive deficits profoundly affecting their quality of life. As the Plasmodium parasite does not enter the brain, but resides inside erythrocytes and are confined to the lumen of the brain's vasculature, the neuropathogenesis leading to these neurologic sequelae is unclear and under-investigated. Interestingly, postmortem CM pathology differs in brain regions, such as the appearance of haemorragic punctae in white versus gray matter. Various host and parasite factors contribute to the risk of CM, including exposure at a young age, parasite- and host-related genetics, parasite sequestration and the extent of host inflammatory responses. Thus far, several proposed adjunctive treatments have not been successful in the treatment of CM but are highly needed. The region-specific CM neuro-pathogenesis leading to neurologic sequelae is intriguing, but not sufficiently addressed in research. More attention to this may lead to the development of effective adjunctive treatments to address CM neurologic sequelae.

Indexed as

Malaria, CerebralMalaria, FalciparumErythrocytesHumansPlasmodium falciparumQuality of LifeBlood brain barrierCerebral malariaHeterogeneityInflammationNeurologic sequelae

Identifiers

PMID32703204
PMCPMC7376930
OpenAlexW3044365302

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.