Evidence map›Paper›PMID 32705966›Full record

ReviewPharmacogenomics2020

Pharmacogenomics of methadone: a narrative review of the literature.

Senthil Packiasabapathy, Blessed W Aruldhas, Nicole Horn, Brian R Overholser, Sara K Quinney, Janelle S Renschler, Senthilkumar Sadhasivam

Open access · greenAbstract readReview
In one paragraph

Review in Pharmacogenomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. The Evaluation ofMetabolites · 2023
    Article
  7. Influence ofLife (Basel, Switzerland) · 2023
    Article
  8. Review
  9. Article
  10. Pharmacogenomics of Opioid Treatment for Pain Management.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  11. Article
  12. Association ofBasic and clinical neuroscience
    Article
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Senthil PackiasabapathyDepartment of Anesthesia, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-0248-5430
Blessed W AruldhasDepartment of Anesthesia, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-2082-6454
Nicole HornDepartment of Anesthesia, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Brian R OverholserDivision of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-3055-9916
Sara K QuinneyDivision of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-6554-0695
Janelle S RenschlerDepartment of Anesthesia, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-4197-3808
Senthilkumar SadhasivamDepartment of Anesthesia, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-3689-8313
Indiana University School of MedicineChristian Medical College, Vellore · INGTx (United States) · USUniversity of Indianapolis · US

Funding

Perioperative Precision Medicine: Translating Science to Clinical Practice to Improve Safety and Efficacy of Opioids in Neonates, Children and Nursing MothersU01TR003719 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Senthilkumar Sadhasivam · 2022 to 2026
$4.4M
Effects of Opioid Use Disorder in Pregnancy on Long-Term Maternal and Child OutcomesR01HD096800 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SADHASIVAM, SENTHILKUMAR · 2018 to 2022
$3.1M
Pharmacogenetics of Oxycodone, Personalized Care and Persistent Surgical PainR01HD089458 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI SADHASIVAM, SENTHILKUMAR · 2016 to 2020
$2.5M
Bedside prediction of opioid-induced respiratory depression in children with pupillometryR21HD094311 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI SADHASIVAM, SENTHILKUMAR · 2018 to 2019
$433k
NCATS NIH HHS U01 TR003719NICHD NIH HHS R01 HD089458NICHD NIH HHS R01 HD096800NICHD NIH HHS R21 HD094311
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Analgesics, OpioidAnimalsGenetic VariationHumansMethadoneOpiate Substitution TreatmentOpioid-Related DisordersPharmacogeneticsAnalgesics, OpioidMethadonegene variantsmethadoneopioidopioid maintenance therapypersonalized analgesiapharmacodynamicspharmacogeneticspharmacogenomicspharmacokineticspolymorphism

Identifiers

PMID32705966
PMCPMC7444627
OpenAlexW3045423406

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.