Evidence map›Paper›PMID 32707767›Full record

ArticleCells2020

Cystitis-Related Bladder Pain Involves ATP-Dependent HMGB1 Release from Macrophages and Its Downstream H

Shiori Hiramoto, Maho Tsubota, Kaoru Yamaguchi, Kyoko Okazaki, Aya Sakaegi, Yuki Toriyama, Junichi Tanaka, Fumiko Sekiguchi, Hiroyasu Ishikura, Hidenori Wake and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Article
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  4. HMGB1-Induced Neurite Outgrowth in the Dorsal Root Ganglion Neurons and Regeneration Priming after their Axonal Injury by Sciatic Nerve Crush.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Shiori HiramotoLaboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University (Formerly Known as Kinki University), Higashi-Osaka 577-8502, Japan.
Maho TsubotaLaboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University (Formerly Known as Kinki University), Higashi-Osaka 577-8502, Japan.
Kaoru YamaguchiLaboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University (Formerly Known as Kinki University), Higashi-Osaka 577-8502, Japan.
Kyoko OkazakiLaboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University (Formerly Known as Kinki University), Higashi-Osaka 577-8502, Japan.
Aya SakaegiLaboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University (Formerly Known as Kinki University), Higashi-Osaka 577-8502, Japan.
Yuki ToriyamaLaboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University (Formerly Known as Kinki University), Higashi-Osaka 577-8502, Japan.
Junichi TanakaLaboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University (Formerly Known as Kinki University), Higashi-Osaka 577-8502, Japan.
Fumiko SekiguchiLaboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University (Formerly Known as Kinki University), Higashi-Osaka 577-8502, Japan.
Hiroyasu IshikuraDivision of Emergency and Critical Care Medicine, Fukuoka University Hospital, Fukuoka 814-0180, Japan.
Hidenori WakeDepartment of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.ORCID 0000-0002-0160-7379
Masahiro NishiboriDepartment of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
Huy Du NguyenFaculty of Engineering, University of Toyama, Toyama 930-8555, Japan.
Takuya OkadaFaculty of Engineering, University of Toyama, Toyama 930-8555, Japan.
Naoki ToyookaFaculty of Engineering, University of Toyama, Toyama 930-8555, Japan.ORCID 0000-0002-9568-1528
Atsufumi KawabataLaboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University (Formerly Known as Kinki University), Higashi-Osaka 577-8502, Japan.ORCID 0000-0002-3163-807X
Kindai University · JPUniversity of Toyama · JPFukuoka University Hospital · JPOkayama University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cystitis-related bladder pain involves RAGE activation by HMGB1, and increased Ca

Indexed as

AcroleinAdenosine TriphosphateAnimalsCalcium Channels, T-TypeCyclophosphamideCystathionine gamma-LyaseCystitis, InterstitialDisease Models, AnimalFemaleHMGB1 ProteinMacrophagesMaleMiceMice, KnockoutReceptor for Advanced Glycation End ProductsSignal TransductionAcroleinAdenosine TriphosphateAger protein, mouseCacna1h protein, mouseCalcium Channels, T-TypeCyclophosphamideCystathionine gamma-LyaseHMGB1 ProteinHMGB1 protein, mousehydrogen sulfiteReceptor for Advanced Glycation End ProductsSulfitesAdenosine triphosphate (ATP)Cav3.2 T-type Ca2+ channelcyclophosphamide (CPA)cystathionine-γ-lyase (CSE)high mobility group box 1 (HMGB1)hydrogen sulfide (H2S)interstitial cystitis/bladder pain syndrome (IC/BPS)macrophagereactive oxygen species (ROS)receptor for advanced glycation end products (RAGE)

Identifiers

PMID32707767
PMCPMC7463894
OpenAlexW3044051634

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.