Evidence map›Paper›PMID 32712770›Full record

ArticleCell biology and toxicology2021

Comparative study of the effects of ziram and disulfiram on human monocyte-derived macrophage functions and polarization: involvement of zinc.

Melissa Parny, José Bernad, Mélissa Prat, Marie Salon, Agnès Aubouy, Elsa Bonnafé, Agnès Coste, Bernard Pipy, Michel Treilhou

Abstract read
PubMed Publisher
In one paragraph

Article in Cell biology and toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Trace elements and metal nanoparticles: mechanistic approaches to mitigating chemotherapy-induced toxicity-a review of literature evidence.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Melissa ParnyEA7417, BTSB, Université Fédérale Toulouse Midi-Pyrénées, INU Champollion, Albi, France.
José BernadPHARMADEV UMR 152, Institut de Recherche pour le Développement (IRD), Université Paul Sabatier Toulouse 3, Toulouse, France.
Mélissa PratPHARMADEV UMR 152, Institut de Recherche pour le Développement (IRD), Université Paul Sabatier Toulouse 3, Toulouse, France.
Marie SalonPHARMADEV UMR 152, Institut de Recherche pour le Développement (IRD), Université Paul Sabatier Toulouse 3, Toulouse, France.
Agnès AubouyPHARMADEV UMR 152, Institut de Recherche pour le Développement (IRD), Université Paul Sabatier Toulouse 3, Toulouse, France.
Elsa BonnaféEA7417, BTSB, Université Fédérale Toulouse Midi-Pyrénées, INU Champollion, Albi, France.
Agnès CostePHARMADEV UMR 152, Institut de Recherche pour le Développement (IRD), Université Paul Sabatier Toulouse 3, Toulouse, France.
Bernard PipyPHARMADEV UMR 152, Institut de Recherche pour le Développement (IRD), Université Paul Sabatier Toulouse 3, Toulouse, France. bernard.pipy@inserm.fr.ORCID 0000-0001-8060-7029
Michel TreilhouEA7417, BTSB, Université Fédérale Toulouse Midi-Pyrénées, INU Champollion, Albi, France.
Université Toulouse III - Paul Sabatier · FRCentre Universitaire Jean-François-Champollion · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ziram, a zinc dithiocarbamate is widely used worldwide as a fungicide in agriculture. In order to investigate ziram-induced changes in macrophage functions and polarization, human monocytes-derived macrophages in culture were treated with ziram at 0.01-10 μmol.L

Indexed as

AntioxidantsApoptosisCell PolarityChemokine CCL2DisulfiramFungicides, IndustrialHumansInterleukin-1betaInterleukin-6MacrophagesOxidative StressTumor Necrosis Factor-alphaZincZiramAntioxidantsCCL2 protein, humanChemokine CCL2DisulfiramFungicides, IndustrialIL1B protein, humanInterleukin-1betaInterleukin-6Tumor Necrosis Factor-alphaZincZiramCytokinesMacrophagesOxidative burstPesticidesPhagocytosisPolarization

Identifiers

PMID32712770
OpenAlexW3044153450

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.