Evidence map›Paper›PMID 32718805›Full record

ArticleJournal of Ayurveda and integrative medicine

Prakriti phenotypes as a stratifier of gut microbiome: A new frontier in personalized medicine?

Apoorva Jnana, Thokur Sreepathy Murali, Kanive Parashiva Guruprasad, Kapaettu Satyamoorthy

Abstract read
In one paragraph

Article in Journal of Ayurveda and integrative medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
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  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Ayurgenomics and Modern Medicine.Medicina (Kaunas, Lithuania) · 2020
    Review
  9. Review
  10. Ayurvedic Biology and road ahead: The first decade.Journal of Ayurveda and integrative medicine
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Apoorva JnanaDepartment of Biotechnology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, India.
Thokur Sreepathy MuraliDepartment of Biotechnology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, India.
Kanive Parashiva GuruprasadDepartment of Ageing Research, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, India; Centre for Ayurvedic Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, India.
Kapaettu SatyamoorthyDepartment of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, India; Centre for Ayurvedic Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, India. Electronic address: ksatyamoorthy@manipal.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ayurveda has a rich history and its significance woven deeply in the Indian culture. The concept of prakriti (a person's "nature" or constitutional type determined by the proportion of three doshas, namely - vata, pitta and kapha) in Ayurveda is deeply rooted in personalized health management. While the attributes of prakriti has been established to have a genomic basis, there is dearth of elaborate evidences linking prakriti with manifestation of diseases. Next generation sequencing studies have provided a causal link between variation in the gut microbiome and its effect on an individual's fitness. Separately, reports have identified gut microbial patterns associated with several host variables such as geography, age, diet and extreme prakriti phenotypes. Recently, few reports have identified a "core gut microbiome" consisting of Bacteroides, Faecalibacterium, Prevotella and Ruminococcus prevalent across the Indian population; however, a few bacterial genera were specifically enriched in certain prakritis. Hence, in this review we aim to analyse the role of prakriti variations on dysbiosis of the gut microbiome and concomitantly its effect on human health. We suggest that prakriti phenotyping can function as a potential stratifier of the gut microbiome in a given population and may provide evidence for the conceptual framework of personalized medicine in Ayurvedic system of medicine.

Indexed as

AyurvedaGut microbiomeMetagenomicsPersonalized medicinePrakriti

Identifiers

PMID32718805
PMCPMC7527847

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.