ArticleScience translational medicine2020
Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents.
Article in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 93 citations in OpenAlex.
- "Tone-Arm" Neuromodulation MEMS Microcoil for In Vivo Imaging.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- From Physical Replacement to Biological Symbiosis: Evolutionary Paradigms and Future Prospects of Auditory Reconstruction Brain-Computer Interfaces.Micromachines · 2026Review
- High-power pulsed electrochemiluminescence for optogenetic manipulation of Drosophila larval behaviour.Light, science & applications · 2026Article
- Channelrhodopsin variants for high-rate optogenetic neurostimulation at low light intensities.EMBO molecular medicine · 2026Article
- Efficient and sustained optogenetic control of sensory and cardiac systems.Nature biomedical engineering · 2026Article
- The auditory nerve implant-concept and device description of a novel electrical auditory prosthesis.Bioelectronic medicine · 2025Review
- 3D-printed optogenetic neural probe integrated with microfluidic tube for opsin/drug delivery.Scientific reports · 2025Article
- Design considerations for optogenetic applications of soft micro-LED-based device systems across diverse nervous systems.Bioactive materials · 2025Review
- 3D virtual histology of rodent and primate cochleae with multi-scale phase-contrast X-ray tomography.Scientific reports · 2025Article
- Inner Ear Gene Therapy: An Overview from Bench to Bedside.Molecular diagnosis & therapy · 2025Review
- Study on Recovery Strategy of Hearing Loss & SGN Regeneration Under Physical Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Improved optogenetic modification of spiral ganglion neurons for future optical cochlear implants.Theranostics · 2025Article
- Combined-electrical optogenetic stimulation but not channelrhodopsin kinetics improves the fidelity of high rate stimulation in the auditory pathway in mice.Scientific reports · 2024Article
- Fabrication and Characterization of PDMS Waveguides for Flexible Optrodes.Advanced healthcare materials · 2024Article
- Wireless magnetoelectrically powered organic light-emitting diodes.Science advances · 2024Article
- Fraxicon for Optical Applications with Aperture ∼1 mm: Characterisation Study.Nanomaterials (Basel, Switzerland) · 2024Article
- Decreasing the physical gap in the neural-electrode interface and related concepts to improve cochlear implant performance.Frontiers in neuroscience · 2024Review
- Review
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
- Thermal safety considerations for implantable micro-coil design.Journal of neural engineering · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 1 country.
Funding
Abstract
When hearing fails, electrical cochlear implants (eCIs) provide the brain with auditory information. One important bottleneck of CIs is the poor spectral selectivity that results from the wide current spread from each of the electrode contacts. Optical CIs (oCIs) promise to make better use of the tonotopic order of spiral ganglion neurons (SGNs) inside the cochlea by spatially confined stimulation. Here, we established multichannel oCIs based on light-emitting diode (LED) arrays and used them for optical stimulation of channelrhodopsin (ChR)-expressing SGNs in rodents. Power-efficient blue LED chips were integrated onto microfabricated 15-μm-thin polyimide-based carriers comprising interconnecting lines to address individual LEDs by a stationary or mobile driver circuitry. We extensively characterized the optoelectronic, thermal, and mechanical properties of the oCIs and demonstrated stability over weeks in vitro. We then implanted the oCIs into ChR-expressing rats and gerbils, and characterized multichannel optogenetic SGN stimulation by electrophysiological and behavioral experiments. Improved spectral selectivity was directly demonstrated by recordings from the auditory midbrain. Long-term experiments in deafened ChR-expressing rats and in nontreated control animals demonstrated specificity of optogenetic stimulation. Behavioral studies on animals carrying a wireless oCI sound processor revealed auditory percepts. This study demonstrates hearing restoration with improved spectral selectivity by an LED-based multichannel oCI system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.