Evidence map›Paper›PMID 32721906›Full record

ArticleIEEE transactions on cybernetics2022

Attention-Guided Hybrid Network for Dementia Diagnosis With Structural MR Images.

Chunfeng Lian, Mingxia Liu, Yongsheng Pan, Dinggang Shen

Abstract read
In one paragraph

Article in IEEE transactions on cybernetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. [Research on the application of convolution neural network in the diagnosis of Alzheimer's disease].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chunfeng Lian
Mingxia Liu
Yongsheng Pan
Dinggang Shen

Funding

Quantifying Brain Abnormality by Multimodality Neuroimage Analysis,R01AG041721 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, MINGXIA · 2012 to 2019
$3.0M
Analyzing Large-Scale Neuroimaging Data in Alzheimer's DiseaseRF1AG053867 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2016 to 2016
$2.5M
NIA NIH HHS R01 AG041721NIA NIH HHS RF1 AG053867
6 · The paper itself

Abstract

Deep-learning methods (especially convolutional neural networks) using structural magnetic resonance imaging (sMRI) data have been successfully applied to computer-aided diagnosis (CAD) of Alzheimer's disease (AD) and its prodromal stage [i.e., mild cognitive impairment (MCI)]. As it is practically challenging to capture local and subtle disease-associated abnormalities directly from the whole-brain sMRI, most of those deep-learning approaches empirically preselect disease-associated sMRI brain regions for model construction. Considering that such isolated selection of potentially informative brain locations might be suboptimal, very few methods have been proposed to perform disease-associated discriminative region localization and disease diagnosis in a unified deep-learning framework. However, those methods based on task-oriented discriminative localization still suffer from two common limitations, that is: 1) identified brain locations are strictly consistent across all subjects, which ignores the unique anatomical characteristics of each brain and 2) only limited local regions/patches are used for model training, which does not fully utilize the global structural information provided by the whole-brain sMRI. In this article, we propose an attention-guided deep-learning framework to extract multilevel discriminative sMRI features for dementia diagnosis. Specifically, we first design a backbone fully convolutional network to automatically localize the discriminative brain regions in a weakly supervised manner. Using the identified disease-related regions as spatial attention guidance, we further develop a hybrid network to jointly learn and fuse multilevel sMRI features for CAD model construction. Our proposed method was evaluated on three public datasets (i.e., ADNI-1, ADNI-2, and AIBL), showing superior performance compared with several state-of-the-art methods in both tasks of AD diagnosis and MCI conversion prediction.

Indexed as

Alzheimer DiseaseCognitive DysfunctionAttentionBrainHumansMagnetic Resonance ImagingNeuroimaging

Identifiers

PMID32721906
PMCPMC7855081

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.