Evidence map›Paper›PMID 32722194›Full record

ArticleVaccines2020

Transcriptomic and Metabolic Responses to a Live-Attenuated

Johannes B Goll, Shuzhao Li, James L Edwards, Steven E Bosinger, Travis L Jensen, Yating Wang, William F Hooper, Casey E Gelber, Katherine L Sanders, Evan J Anderson and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. The immune response toFrontiers in microbiology · 2025
    Review
  3. iScience · 2023
    Article
  4. Article
  5. Article
  6. Bioengineered · 2022
    Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Johannes B GollThe Emmes Company, Rockville, MD 20850, USA.ORCID 0000-0002-9968-4080
Shuzhao LiDepartments of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
James L EdwardsDepartment of Chemistry, Saint Louis University, St Louis, MO 63103, USA.
Steven E BosingerYerkes National Primate Research Center, Secret Path, Atlanta, GA 30329, USA.
Travis L JensenThe Emmes Company, Rockville, MD 20850, USA.ORCID 0000-0002-0322-0469
Yating WangDepartments of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
William F HooperThe Emmes Company, Rockville, MD 20850, USA.
Casey E GelberThe Emmes Company, Rockville, MD 20850, USA.
Katherine L SandersDepartment of Chemistry, Saint Louis University, St Louis, MO 63103, USA.
Evan J AndersonDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0002-1576-4420
Nadine RouphaelEmory Vaccine Center, Emory University, Atlanta, GA 30322, USA.
Muktha S NatrajanEmory Vaccine Center, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0003-1854-0382
Robert A JohnsonBiomedical Advanced Research and Development Authority, U. S. Department of Health and Human Services, Washington, DC 20201, USA.
Patrick SanzDivision of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA.
Daniel HoftDivision of Infectious Diseases, Allergy and Immunology, Saint Louis University Health Sciences Center, St. Louis, MO 63104, USA.
Mark J MulliganDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Emory University · USEmmes (United States) · USSaint Louis University · USBiomedical Advanced Research and Development Authority · USNational Institutes of Health · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Illumina NovaSeq 6000 High Throughput DNA Sequencer for Emory UniversityS10OD026799 · OD · EMORY UNIVERSITY · PI BOSINGER, STEVEN EDWARD · 2019 to 2019
$985k
NIH HHS HHSN272200800013CNIH HHS HHSN272201300018INIH HHS HHSN272201300021INIH HHS P51 OD011132NIH HHS S10 OD026799
6 · The paper itself

Abstract

The immune response to live-attenuated

Indexed as

DVC-LVSFrancisella tularenis vaccineFrancisella tularensishuman immune responseinnate immune signalinginterferon α/β signalingLC–MSmetabolomicsNF-κBNOD-like receptorRNA-Seqsuppression of immune responseTLRTNFtularemia vaccine

Identifiers

PMID32722194
PMCPMC7563297
OpenAlexW3045038379

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.