ArticleAnnals of the rheumatic diseases2020
Genome-wide association study in a Korean population identifies six novel susceptibility loci for rheumatoid arthritis.
Article in Annals of the rheumatic diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Novel susceptibility loci for steroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus.Human molecular genetics · 2022Pooled it
- Identification and validation of KLRB1-related biomarkers in rheumatoid arthritis.Scientific reports · 2026Article
- Involvement of SWAP-70 in proteolipid protein-induced experimental autoimmune encephalomyelitis.Turkish journal of medical sciences · 2026Article
- TLR7 and TLR9 have overlapping but distinct roles in systemic lupus erythematosus and Sjögren's disease.Frontiers in immunology · 2026Review
- Integrative GWAS and Mendelian randomization study of rheumatoid arthritis based on the 2019 UK Biobank questionnaire.Clinical rheumatology · 2025Article
- Targeting Therapeutic Windows for Rheumatoid Arthritis Prevention.Chinese journal of integrative medicine · 2024Review
- Systemic proteome adaptions to 7-day complete caloric restriction in humans.Nature metabolism · 2024Article
- A Summary on the Genetics of Systemic Lupus Erythematosus, Rheumatoid Arthritis, Systemic Sclerosis, and Sjögren's Syndrome.Clinical reviews in allergy & immunology · 2023Review
- Integrative multi-omics approaches to explore immune cell functions: Challenges and opportunities.iScience · 2023Review
- Chemokines and chemokine receptors as promising targets in rheumatoid arthritis.Frontiers in immunology · 2023Review
- Role of signaling lymphocytic activation molecule family of receptors in the pathogenesis of rheumatoid arthritis: insights and application.Frontiers in pharmacology · 2023Review
- Genetic variant in SPAG16 is associated with the susceptibility of ACPA-positive rheumatoid arthritis possibly via regulation of MMP-3.Journal of orthopaedic surgery and research · 2022Article
- Correlation of CRP genotypes with serum CRP levels and the risk of rheumatoid arthritis in Chinese Han population.Clinical rheumatology · 2022Article
- Interleukin-13 Receptor α1-Mediated Signaling Regulates Age-Associated/Autoimmune B Cell Expansion and Lupus Pathogenesis.Arthritis & rheumatology (Hoboken, N.J.) · 2022Article
- Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis.Translational psychiatry · 2022Article
- SLAMF6 is associated with the susceptibility and severity of rheumatoid arthritis in the Chinese population.Journal of orthopaedic surgery and research · 2022Article
- Genetics of rheumatoid arthritis.Seminars in immunopathology · 2022Review
- Association Study of Anticitrullinated Peptide Antibody Status with Clinical Manifestations and SNPs in Patients Affected with Rheumatoid Arthritis: A Pilot Study.Disease markers · 2022Article
- Recent advances in understanding the genetic basis of systemic lupus erythematosus.Seminars in immunopathology · 2022Review
- The Contribution of Genetic Variation and Aberrant Methylation of Aryl Hydrocarbon Receptor Signaling Pathway Genes to Rheumatoid Arthritis.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
24 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveGenome-wide association studies (GWAS) in rheumatoid arthritis (RA) have discovered over 100 RA loci, explaining patient-relevant RA pathogenesis but showing a large fraction of missing heritability. As a continuous effort, we conducted GWAS in a large Korean RA case-control population.
methodsWe newly generated genome-wide variant data in two independent Korean cohorts comprising 4068 RA cases and 36 487 controls, followed by a whole-genome imputation and a meta-analysis of the disease association results in the two cohorts. By integrating publicly available omics data with the GWAS results, a series of bioinformatic analyses were conducted to prioritise the RA-risk genes in RA loci and to dissect biological mechanisms underlying disease associations.
resultsWe identified six new RA-risk loci (
conclusionThis study identified six new RA-associated loci that contributed to better understanding of the genetic aetiology and biology in RA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.