Evidence map›Paper›PMID 32728376›Full record

ArticleNano today2020

Amyloidosis Inhibition, a New Frontier of the Protein Corona.

Pengyu Chen, Feng Ding, Rong Cai, Ibrahim Javed, Wen Yang, Zhenzhen Zhang, Yuhuan Li, Thomas P Davis, Pu Chun Ke, Chunying Chen

Abstract read
In one paragraph

Article in Nano today, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Micro- and Nanoplastics' Effects on Protein Folding and Amyloidosis.International journal of molecular sciences · 2022
    Review
  9. Review
  10. Dynamic intracellular exchange of nanomaterials' protein corona perturbs proteostasis and remodels cell metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. The membrane axis of Alzheimer's nanomedicine.Advanced nanobiomed research · 2021
    Article
  15. Emerging Nanotechnology for Treatment of Alzheimer's and Parkinson's Disease.Frontiers in bioengineering and biotechnology · 2021
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pengyu ChenMaterials Research and Education Center, Auburn University, Auburn, AL 36849, United States.
Feng DingDepartment of Physics and Astronomy, Clemson University, Clemson, SC 29634, United States.
Rong CaiCAS Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China.
Ibrahim JavedARC Center of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia.
Wen YangMaterials Research and Education Center, Auburn University, Auburn, AL 36849, United States.
Zhenzhen ZhangDepartment of Physics and Astronomy, Clemson University, Clemson, SC 29634, United States.
Yuhuan LiZhongshan Hospital, Fudan University, 111 Yixueyuan Rd, Xuhui District, Shanghai, China.
Thomas P DavisARC Center of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia.
Pu Chun KeZhongshan Hospital, Fudan University, 111 Yixueyuan Rd, Xuhui District, Shanghai, China.
Chunying ChenCAS Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China.

Funding

Purchase of a modularized confocal microscopeR35GM133795 · NIGMS · AUBURN UNIVERSITY AT AUBURN · PI Pengyu Chen · 2019 to 2026
$3.3M
Inhibition of Human Islet Amyloid Polypeptide AggregationR35GM119691 · NIGMS · CLEMSON UNIVERSITY · PI DING, FENG · 2016 to 2020
$1.9M
NIGMS NIH HHS R35 GM119691NIGMS NIH HHS R35 GM133795
6 · The paper itself

Abstract

The protein corona has served as a central dogma and a nuisance to the applications of nanomedicine and nanobiotechnology for well over a decade. Here we introduce the emerging field of amyloidosis inhibition, which aims to understand and harness the interfacial phenomena associated with a nanoparticle interacting with pathogenic amyloid proteins. Much of this interaction correlates with our understanding of the protein corona, and yet much differs, as elaborated for the first time in this

Indexed as

amyloidosisamyloid protein coronacytokinenanoparticle inhibitorprotein corona

Identifiers

PMID32728376
PMCPMC7388636

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.