Evidence map›Paper›PMID 32729936›Full record

ArticleBiotechnology and bioengineering2020

Regulation of adipose tissue inflammation and systemic metabolism in murine obesity by polymer implants loaded with lentiviral vectors encoding human interleukin-4.

Richard Youngblood, Carmen G Flesher, Jennifer Delproposto, Nicki A Baker, Christopher K Neeley, Fanghua Li, Carey N Lumeng, Lonnie D Shea, Robert W O'Rourke

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biotechnology and bioengineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Richard YoungbloodDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.
Carmen G FlesherDepartment of Surgery, University of Michigan Medical School, Ann Arbor, Michigan.
Jennifer DelpropostoDepartment of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan.
Nicki A BakerDepartment of Surgery, University of Michigan Medical School, Ann Arbor, Michigan.
Christopher K NeeleyDepartment of Surgery, University of Michigan Medical School, Ann Arbor, Michigan.
Fanghua LiDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.
Carey N LumengDepartment of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan.
Lonnie D SheaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0002-9296-9673
Robert W O'RourkeDepartment of Surgery, University of Michigan Medical School, Ann Arbor, Michigan.ORCID 0000-0002-4038-4198
University of Michigan · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joyce Lee · 2010 to 2026
$20.3M
Regulation of Adipose Tissue Inflammation By Antigen Presenting CellsR01DK090262 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, CAREY N · 2011 to 2024
$5.3M
Cellular Biotechnology Training Program (CBTP) - Years 31-35T32GM145304 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Guizhi Zhu · 2022 to 2026
$2.6M
Adipose Tissue Macrophage Control of Metabolic Dysfunction in DiabetesR01DK115190 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, CAREY N, O'ROURKE, ROBERT W · 2017 to 2020
$2.3M
CSRD VA I01 CX001811NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK090262NIDDK NIH HHS R01 DK115190NIGMS NIH HHS T32 GM145304
6 · The paper itself

Abstract

Dysfunctional adipose tissue plays a central role in the pathogenesis of the obesity-related metabolic disease, including type 2 diabetes. Targeting adipose tissue using biopolymer implants is a novel therapeutic approach for metabolic disease. We transplanted porous poly(lactide-co-glycolide) (PLG) implants coated with human interleukin-4 (hIL-4)-expressing lentivirus into epididymal white adipose tissue (eWAT) of mice fed a high-fat diet. Tissue and systemic inflammation and metabolism were studied with flow cytometry, immunohistochemistry, quantitative real-time polymerase chain reaction, adipose tissue histology, and in vivo glucose tolerance testing at 2 and 10 weeks of a high-fat diet. PLG implants carrying hIL-4-expressing lentivirus implanted into epididymal white adipose tissue of mice-regulated adipose tissue inflammation, including increased CD3

Indexed as

Implants, ExperimentalInterleukin-4LentivirusTransduction, GeneticAdipose TissueAnimalsDisease Models, AnimalHumansInflammationMaleMiceObesityIL4 protein, humanInterleukin-4adipose tissuebiomaterialinflammationinsulin resistanceobesitypoly(lactide-co-glycolide)

Identifiers

PMID32729936
PMCPMC8358590
OpenAlexW3046704171

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.