Evidence map›Paper›PMID 32733483›Full record

ArticleFrontiers in immunology2020

An Unusual MHC Molecule Generates Protective CD8+ T Cell Responses to Chronic Infection.

Alexandra Tsitsiklis, Derek J Bangs, Lydia K Lutes, Shiao W Chan, Kristina M Geiger, Andrew J Modzelewski, Lara Labarta-Bajo, Yang Wang, Elina I Zuniga, Shaodong Dai and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Alexandra TsitsiklisDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United States.
Derek J BangsDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United States.
Lydia K LutesDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United States.
Shiao W ChanDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United States.
Kristina M GeigerDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United States.
Andrew J ModzelewskiDivision of Cell and Developmental Biology, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United States.
Lara Labarta-BajoDivision of Biological Sciences, University of California, San Diego, La Jolla, CA, United States.
Yang WangDepartment of Pharmaceutical Sciences, University of Colorado School of Pharmacy, Aurora, CO, United States.
Elina I ZunigaDivision of Biological Sciences, University of California, San Diego, La Jolla, CA, United States.
Shaodong DaiDepartment of Pharmaceutical Sciences, University of Colorado School of Pharmacy, Aurora, CO, United States.
Ellen A RobeyDivision of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, United States.
University of California, Berkeley · USUniversity of California, San Diego · USUniversity of Colorado Denver · US

Funding

Inhibitory Pathways Underlying Viral Persistence In VivoR01AI081923 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Elina I Zuniga · 2009 to 2026
$6.6M
Visualizing of Immune Responses to Toxoplasma GondiiR01AI065537 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI ROBEY, ELLEN A · 2005 to 2019
$5.1M
Immunology & Pathogenesis Program Training GrantT32AI100829 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Gregory M Barton, ELLEN A ROBEY · 2012 to 2026
$4.7M
Molecular Basis of T Cell Recognition of Metal IonsR01ES025797 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI DAI, SHAODONG · 2015 to 2019
$1.8M
Regulation of T cell responses during chronic infection by Toxoplasma gondiiR01AI093132 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI ROBEY, ELLEN A · 2011 to 2015
$948k
NIAID NIH HHS R01 AI065537NIAID NIH HHS R01 AI081923NIAID NIH HHS R01 AI093132NIAID NIH HHS T32 AI100829NIEHS NIH HHS R01 ES025797
6 · The paper itself

Abstract

The CD8+ T cell response to the intracellular parasite

Indexed as

AnimalsAntigen PresentationAntigens, ProtozoanCD8-Positive T-LymphocytesCells, CulturedChronic DiseaseDisease ResistanceEpitopes, T-LymphocyteHerpesviridae InfectionsHistocompatibility Antigen H-2DImmediate-Early ProteinsMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicMuromegalovirusAntigens, ProtozoanEpitopes, T-LymphocyteGRA6 protein, Toxoplasma gondiiHistocompatibility Antigen H-2DIE1 protein, cytomegalovirusImmediate-Early ProteinsPeptidesProtozoan ProteinsCD8+ T cellschronic infectionexhaustionMHCToxoplasma gondii

Identifiers

PMID32733483
PMCPMC7360836
OpenAlexW3037830188

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.