Evidence map›Paper›PMID 32737279›Full record

ArticleIET systems biology2020

Efficient prediction of drug-drug interaction using deep learning models.

Prashant Kumar Shukla, Piyush Kumar Shukla, Poonam Sharma, Paresh Rawat, Jashwant Samar, Rahul Moriwal, Manjit Kaur

Abstract read
In one paragraph

Article in IET systems biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

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  14. Deep Transfer Learning Based Classification Model for COVID-19 Disease.Ingenierie et recherche biomedicale : IRBM = Biomedical engineering and research · 2022
    Article
  15. Article
  16. Review
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  18. Article
  19. Evolving Long Short-Term Memory Network-Based Text Classification.Computational intelligence and neuroscience · 2022
    Article
  20. Medical Image Captioning Using Optimized Deep Learning Model.Computational intelligence and neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Prashant Kumar ShuklaDepartment of Computer Science and Engineering, School of Engineering & Technology, Jagran Lake City University (JLU), Bhopal, MP, India.
Piyush Kumar ShuklaDepartment of Computer Science and Engineering, University Institute of Technology, RGPV, Bhopal, MP, India.
Poonam SharmaDepartment of Computer Science & Engineering, Visvesvaraya National Institute of Technology, Nagpur, India.
Paresh RawatDepartment of Electronics and Communication Engineering, Sagar Institute of Science & Technology (SISTec), Gandhi Nagar, Bhopal, MP, India.
Jashwant SamarDepartment of Computer Science and Engineering, University Institute of Technology, RGPV, Bhopal, MP, India.
Rahul MoriwalDepartment of Computer Science and Engineering-AITR Indore, MP, India.
Manjit KaurDepartment of Computer and Communication Engineering, School of Computing and Information Technology, Manipal University Jaipur, Rajasthan, India. manjit.kaur@jaipur.manipal.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A drug-drug interaction or drug synergy is extensively utilised for cancer treatment. However, prediction of drug-drug interaction is defined as an ill-posed problem, because manual testing is only implementable on small group of drugs. Predicting the drug-drug interaction score has been a popular research topic recently. Recently many machine learning models have proposed in the literature to predict the drug-drug interaction score efficiently. However, these models suffer from the over-fitting issue. Therefore, these models are not so-effective for predicting the drug-drug interaction score. In this work, an integrated convolutional mixture density recurrent neural network is proposed and implemented. The proposed model integrates convolutional neural networks, recurrent neural networks and mixture density networks. Extensive comparative analysis reveals that the proposed model significantly outperforms the competitive models.

Indexed as

Deep LearningDrug InteractionsComputational BiologyHumansNeural Networks, Computer

Identifiers

PMID32737279
PMCPMC8687321

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.