Evidence map›Paper›PMID 32743575›Full record

ArticlebioRxiv : the preprint server for biology2020

Simulations support the interaction of the SARS-CoV-2 spike protein with nicotinic acetylcholine receptors.

A Sofia F Oliveira, Amaurys Avila Ibarra, Isabel Bermudez, Lorenzo Casalino, Zied Gaieb, Deborah K Shoemark, Timothy Gallagher, Richard B Sessions, Rommie E Amaro, Adrian J Mulholland

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 20 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

A Sofia F OliveiraCentre for Computational Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, UK.
Amaurys Avila IbarraResearch Software Engineering, Advanced Computing Research Centre, University of Bristol, Bristol BS1 5QD, UK.
Isabel BermudezDepartment of Biological and Medical Sciences, Oxford Brookes University, Oxford OX30BP, UK.
Lorenzo CasalinoDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093 USA.
Zied GaiebDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093 USA.
Deborah K ShoemarkSchool of Biochemistry, University of Bristol, Bristol BS8 1DT, UK.
Timothy GallagherCentre for Computational Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, UK.
Richard B SessionsSchool of Biochemistry, University of Bristol, Bristol BS8 1DT, UK.
Rommie E AmaroDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 92093 USA.
Adrian J MulhollandCentre for Computational Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, UK.
University of Bristol · GBUniversity of California San Diego · USOxford Brookes University · GB

Funding

A MULTISCALE APPROACH TO TARGET THE ACHILLES HEEL OF P53 CANCER MUTANTS (Equipment Supplement)R01GM132826 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AMARO, ROMMIE E · 2019 to 2022
$1.3M
Biotechnology and Biological Sciences Research Council BB/L01386X/1NIGMS NIH HHS R01 GM132826
6 · The paper itself

Abstract

Changeux

Identifiers

PMID32743575
PMCPMC7386492
OpenAlexW3043803093

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.