SynthesisJournal of diabetes investigation2021
Association between weight cycling and risk of developing diabetes in adults: A systematic review and meta-analysis.
Synthesis in Journal of diabetes investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Pooled it
- How effective is rejoining a long-term weight loss program? The 5- and 10-year MRI-assessed Follow Interventions Trial (FIT) project.BMC medicine · 2026Trial
- Psychological Determinants of the Weight Cycle: A Review of Perceived Stress and Self-Efficacy.Current obesity reports · 2026Review
- Maternal History of Weight Loss and Prospective Gestational Weight Gain.JAMA network open · 2026Article
- Weight Trajectory Impacts Risk for 10 Distinct Cardiometabolic Diseases.The Journal of clinical endocrinology and metabolism · 2025Article
- Long-term body mass index variability and the risk of cardiometabolic multimorbidity in middle-aged and older adults: Insights from two prospective cohorts.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Article
- Metabolic Scarring: The Persistent Impact of Past Obesity on Long-Term Metabolic Health Despite Weight Loss.Endocrinology, diabetes & metabolism · 2025Article
- Weight Gain, Weight Loss, and Type 2 Diabetes Risk: Evidence From the Atherosclerosis Risk in Communities (ARIC) Study.Endocrinology, diabetes & metabolism · 2025Article
- In Search of Environmental Factors Associated With Global Differences in Birth Weight and BMI.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- The role of immune cells-mediated memory in weight cycling, glucose disorders and insulin resistance.Frontiers in immunology · 2025Review
- Detecting and addressing eating disorders among individuals experiencing food insecurity: considerations for dietetic practice.Frontiers in nutrition · 2025Article
- Cardiometabolic characteristics of weight cycling: results from a mid-South regional comprehensive health care system.Obesity (Silver Spring, Md.) · 2024Article
- Long-term weight patterns and physical activity in gallstones.Scientific reports · 2024Article
- Review
- Adipose tissue fibrosis: the unwanted houseguest invited by obesity.The Journal of endocrinology · 2023Review
- Weight-cycling over 6 years is associated with pain, physical function and depression in the Osteoarthritis Initiative cohort.Scientific reports · 2023Article
- Weekly, Seasonal, and Festive Period Weight Gain Among Australian Adults.JAMA network open · 2023Article
- Weight cycling based on altered immune microenvironment as a result of metaflammation.Nutrition & metabolism · 2023Review
- Body composition as a marker of performance and health in military personnel.Frontiers in sports and active living · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
AIMS/
introductionIn this meta-analysis, we aimed to explore the association between bodyweight cycling (weight fluctuation) and the risk of developing diabetes. MATERIALS AND
methodsWe analyzed data from eligible cohort studies that assessed the association between weight cycling in adults and the risk of developing diabetes from online databases PubMed, Cochrane Library and EMBASE databases (1966 to April 2020). We pooled data using relative risks (RRs) with a random effects model.
resultsA total of 14 studies involving 253,766 participants, including 8,904 diabetes events, were included. One study included eight independent reports, resulting in 21 reports in 14 studies. Summary analysis showed that individuals who suffered weight cycling had a higher risk of diabetes (RR 1.23. 95% confidence interval 1.07-1.41; P = 0.003). However, the association between weight cycling and the risk of developing diabetes was not observed in obese participants (body mass index ≥30 kg/m
conclusionsThe present meta-analysis showed that weight cycling was a strong independent predictor of new-onset diabetes. Future studies are required to detect the causal links between weight cycling and the risk of developing diabetes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.