ReviewNeurobiology of learning and memory2020
The diversity of linkage-specific polyubiquitin chains and their role in synaptic plasticity and memory formation.
Review in Neurobiology of learning and memory, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Non-canonical K27 polyubiquitination is a sex-specific regulator of contextual fear memory in the hippocampus but not the amygdala.Behavioural brain research · 2026Article
- Temporal- and sex-specific changes in proteasome-dependent and independent polyubiquitination in the amygdala during fear memory formation.Learning & memory (Cold Spring Harbor, N.Y.) · 2026Article
- LINC01963 promotes pancreatic ductal adenocarcinoma proliferation via METTL3/IGF2BP2 axis-mediated m⁶A modification of c-Myc.Journal of experimental & clinical cancer research : CR · 2026Article
- Post-translational modifications as a regulatory code for tau function in health and disease.Frontiers in dementia · 2026Review
- Reductions in protein degradation in the retrosplenial cortex regulate contextual fear memory formation in a sex-independent manner.Neurobiology of learning and memory · 2026Article
- Desmosome and Hemidesmosome Release via Exosomes from Retinal Pigmented Epithelium - A Precursor to Epithelial-Mesenchymal Transition in Early AMD?Current eye research · 2025Review
- Cypin regulates K63-linked polyubiquitination to shape synaptic content.Science advances · 2025Article
- Emerging roles for E3 ubiquitin ligases in neural development and disease.Frontiers in cell and developmental biology · 2025Review
- Indirectly acquired fear memories have distinct, sex-specific molecular signatures from directly acquired fear memories.PloS one · 2024Article
- The ubiquitin-proteasome system and learning-dependent synaptic plasticity - A 10 year update.Neuroscience and biobehavioral reviews · 2023Review
- Short-term exposure to an obesogenic diet causes dynamic dysregulation of proteasome-mediated protein degradation in the hypothalamus of female rats.Nutritional neuroscience · 2023Article
- Sex differences in training-induced activity of the ubiquitin proteasome system in the dorsal hippocampus and medial prefrontal cortex of male and female mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Protein SUMOylation is a sex-specific regulator of fear memory formation in the amygdala.Behavioural brain research · 2022Article
- Epigenetic Mechanisms in Memory and Cognitive Decline Associated with Aging and Alzheimer's Disease.International journal of molecular sciences · 2021Review
- Historical perspective and progress on protein ubiquitination at glutamatergic synapses.Neuropharmacology · 2021Review
- Females, but not males, require protein degradation in the hippocampus for contextual fear memory formation.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity.Molecular brain · 2021Article
- Males and females differ in the regulation and engagement of, but not requirement for, protein degradation in the amygdala during fear memory formation.Neurobiology of learning and memory · 2021Article
- Proteomic Analysis Reveals Sex-Specific Protein Degradation Targets in the Amygdala During Fear Memory Formation.Frontiers in molecular neuroscience · 2021Article
- Sex-Specific Linear Polyubiquitination Is a Critical Regulator of Contextual Fear Memory Formation.Frontiers in behavioral neuroscience · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Over the last 20 years, a number of studies have provided strong support for protein degradation mediated by the ubiquitin-proteasome system in synaptic plasticity and memory formation. In this system, target substrates become covalently modified by the small protein ubiquitin through a series of enzymatic reactions involving hundreds of different ligases. While some substrates will acquire only a single ubiquitin, most will be marked by multiple ubiquitin modifications, which link together at specific lysine sites or the N-terminal methionine on the previous ubiquitin to form a polyubiquitin chain. There are at least eight known linkage-specific polyubiquitin chains a target protein can acquire, many of which are independent of the proteasome, and these chains can be homogenous, mixed, or branched in nature, all of which result in different functional outcomes and fates for the target substrate. However, as the focus has remained on protein degradation, much remains unknown about the role of these diverse ubiquitin chains in the brain, particularly during activity- and learning-dependent synaptic plasticity. Here, we review the different types and functions of ubiquitin chains and summarize evidence suggesting a role for these diverse ubiquitin modifications in synaptic plasticity and memory formation. We conclude by discussing how technological limitations have limited our ability to identify and elucidate the role of different ubiquitin chains in the brain and speculate on the future directions and implications of understanding linkage-specific ubiquitin modifications in activity- and learning-dependent synaptic plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.