Evidence map›Paper›PMID 32747882›Full record

ReviewJournal of materials chemistry. B2020

Harnessing biomolecules for bioinspired dental biomaterials.

Nicholas G Fischer, Eliseu A Münchow, Candan Tamerler, Marco C Bottino, Conrado Aparicio

Abstract readReview
In one paragraph

Review in Journal of materials chemistry. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Guidance on biomaterials for periodontal tissue regeneration: Fabrication methods, materials and biological considerations.Dental materials : official publication of the Academy of Dental Materials · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Natural medicine delivery from 3D printed bone substitutes.Journal of controlled release : official journal of the Controlled Release Society · 2024
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nicholas G FischerMinnesota Dental Research Center for Biomaterials and Biomechanics, University of Minnesota, 16-250A Moos Tower, 515 Delaware St. SE, Minneapolis, Minnesota 55455, USA. apari003@umn.edu.
Eliseu A Münchow
Candan Tamerler
Marco C Bottino
Conrado Aparicio

Funding

Minnesota Craniofacial Research Training ProgramT90DE022732 · NIDCR · UNIVERSITY OF MINNESOTA · PI MANSKY, KIM CARPENTER · 2012 to 2023
$4.9M
Peptide-Polymer Engineering Dentin/Adhesive Interfacial Bond IntegrityR01DE025476 · NIDCR · UNIVERSITY OF KANSAS LAWRENCE · PI SPENCER, PAULETTE, TAMERLER-BEHAR, CANDAN · 2015 to 2024
$3.2M
NOVEL THERAPEUTICS TO TREAT NECROTIC TEETH: THE COMBINATORIAL EFFECT OF A 3D DRUG DELIVERY SYSTEM AND SPATIALLY DESIGNED STEM CELL NICHESR01DE026578 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOTTINO, MARCO C · 2017 to 2021
$1.7M
A novel peptide-enhanced class-V dental restorative system with a 3-tier fortificationR01DE026117 · NIDCR · UNIVERSITY OF MINNESOTA · PI APARICIO, CONRADO · 2016 to 2018
$1.1M
A Novel Multilayered Membrane for Periodontal RegenerationK08DE023552 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOTTINO, MARCO C · 2013 to 2017
$716k
Biofunctional sealant with peptides to extend lifespans of Class V restorationsF30DE029105 · NIDCR · UNIVERSITY OF MINNESOTA · PI FISCHER, NICHOLAS G · 2019 to 2025
$277k
NIDCR NIH HHS F30 DE029105NIDCR NIH HHS K08 DE023552NIDCR NIH HHS R01 DE025476NIDCR NIH HHS R01 DE026117NIDCR NIH HHS R01 DE026578NIDCR NIH HHS T90 DE022732
6 · The paper itself

Abstract

Dental clinicians have relied for centuries on traditional dental materials (polymers, ceramics, metals, and composites) to restore oral health and function to patients. Clinical outcomes for many crucial dental therapies remain poor despite many decades of intense research on these materials. Recent attention has been paid to biomolecules as a chassis for engineered preventive, restorative, and regenerative approaches in dentistry. Indeed, biomolecules represent a uniquely versatile and precise tool to enable the design and development of bioinspired multifunctional dental materials to spur advancements in dentistry. In this review, we survey the range of biomolecules that have been used across dental biomaterials. Our particular focus is on the key biological activity imparted by each biomolecule toward prevention of dental and oral diseases as well as restoration of oral health. Additional emphasis is placed on the structure-function relationships between biomolecules and their biological activity, the unique challenges of each clinical condition, limitations of conventional therapies, and the advantages of each class of biomolecule for said challenge. Biomaterials for bone regeneration are not reviewed as numerous existing reviews on the topic have been recently published. We conclude our narrative review with an outlook on the future of biomolecules in dental biomaterials and potential avenues of innovation for biomaterial-based patient oral care.

Indexed as

Amino Acid SequenceAnimalsAntimicrobial Cationic PeptidesBiomineralizationChitosanDental ImplantsDental MaterialsDental Restoration, PermanentDNAHumansImmobilized ProteinsMouth DiseasesPeriodontiumRegenerationSalivary GlandsAntimicrobial Cationic PeptidesChitosanDental ImplantsDental MaterialsDNAImmobilized Proteins

Identifiers

PMID32747882
PMCPMC7544669

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.