Evidence map›Paper›PMID 32759334›Full record

ArticlemSphere2020

Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and

Meaghan H Hancock, Jennifer Mitchell, Felicia D Goodrum, Jay A Nelson

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Viral miRNA regulation of host gene expression.Seminars in cell & developmental biology · 2023
    Review
  9. Review
  10. Hematopoietic stem cells and betaherpesvirus latency.Frontiers in cellular and infection microbiology · 2023
    Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Evasion of the Host Immune Response by Betaherpesviruses.International journal of molecular sciences · 2021
    Review
  18. Article
  19. Review
  20. Role of EGF Receptor Regulatory Networks in the Host Response to Viral Infections.Frontiers in cellular and infection microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Meaghan H HancockVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA hancocme@ohsu.edu.ORCID 0000-0003-2945-0147
Jennifer MitchellVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Felicia D GoodrumDepartment of Immunobiology, BIO5 Institute, University of Arizona, Tucson, Arizona, USA.
Jay A NelsonVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Oregon Health & Science University · USUniversity of Arizona · US

Funding

The Administrative CoreP01AI127335 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI Patrizia Caposio · 2017 to 2026
$24.6M
MOLECULAR ASPECTS OF CYTOMEGALOVIRUS LATENCYR01AI021640 · NIAID · UNIVERSITY OF GUELPH · PI Meaghan H Hancock · 1985 to 2026
$8.1M
Mechanisms of Human Cytomegalovirus Latency in Primary Human Hematopoietic CellsR01AI079059 · NIAID · UNIVERSITY OF ARIZONA · PI GOODRUM, FELICIA D · 2008 to 2018
$4.4M
Molecular Aspects of Cytomegalovirus LatencyR37AI021640 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI HANCOCK, MEAGHAN H · 2018 to 2024
$4.0M
NIAID NIH HHS P01 AI127335NIAID NIH HHS R01 AI021640NIAID NIH HHS R01 AI079059NIAID NIH HHS R37 AI021640
6 · The paper itself

Abstract

Regulation of epidermal growth factor (EGF) receptor (EGFR) signaling is critical for the replication of human cytomegalovirus (HCMV) as well as latency and reactivation in CD34

Indexed as

Signal TransductionAdaptor Proteins, Signal TransducingCell ProliferationCells, CulturedCytomegalovirusDown-RegulationEndothelial CellsErbB ReceptorsFibroblastsGene Expression RegulationHEK293 CellsHost-Pathogen InteractionsHumansMicroRNAsViral ProteinsAdaptor Proteins, Signal TransducingErbB ReceptorsGAB1 protein, humanMicroRNAsViral ProteinscytomegalovirusGAB1miRNAUL138

Identifiers

PMID32759334
PMCPMC7407068
OpenAlexW3047376616

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.