Evidence map›Paper›PMID 32767596›Full record

SynthesisJournal of gastroenterology and hepatology2021

Effects of the herbal medicine Rikkunshito, for functional dyspepsia: A systematic review and meta-analysis.

Seok-Jae Ko, Jiseon Park, Min-Ji Kim, Jinsung Kim, Jae-Woo Park

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of gastroenterology and hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 6 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 6 syntheses or guidelines pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Seok-Jae KoDepartment of Gastroenterology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0002-9902-0938
Jiseon ParkDepartment of Gastroenterology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Min-Ji KimDepartment of Gastroenterology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Jinsung KimDepartment of Gastroenterology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Jae-Woo ParkDepartment of Gastroenterology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Kyung Hee University · KRState University of Papua · ID

Funding

National Research Foundation of Korea NRF-2017R1A2B4010691
6 · The paper itself

Abstract

BACKGROUND AND

aimFunctional dyspepsia (FD) is characterized by chronic and unexplained indigestion at upper abdomen. Because of unsatisfactory effect of conventional treatments, demand is growing for complementary and alternative medicine. Rikkunshito (RKT) is a herbal medicine, which has been widely used for FD in Asia; however, the evidence is lacking. We carried out systematic review and meta-analysis to evaluate the effect and safety of RKT in the treatment of FD.

methodsElectronic databases were searched in April 2019, including PUBMED, EMBASE, and Cochrane Library. All eligible studies should be randomized controlled trials (RCTs) comparing RKT or combination therapy (RKT and western medicine) group to western medicine group. The primary outcome measure was the total clinical efficacy rate (TCE). The secondary outcomes were total dyspepsia symptom scale, gastric emptying rate, gastrin, motilin, recurrence 6 months after treatment, and Hamilton depression rating scale.

resultsFifty-two RCTs with 5475 patients were involved in this systematic review and meta-analysis. Compared with western medicine, RKT showed significant better result, with higher TCE (relative risk = 1.21, 95% confidence interval 1.17 to 1.25, P < 0.001). RKT presented higher reduction of total dyspepsia symptom scale, more improved gastric emptying rate, and lower recurrence 6 months after treatment compared with western medicine. However, there was no significant difference in Hamilton depression rating scale between RKT and western medicine group. Combination therapy brought significant symptom improvement with TCE compared with western medicine alone.

conclusionsRikkunshito and combination therapy might be considered an effective alternative treatment for FD. Further rigorously designed and high-quality RCTs are needed.

Indexed as

PhytotherapyDrugs, Chinese HerbalDrug Therapy, CombinationDyspepsiaFemaleGastric EmptyingHumansMaleRandomized Controlled Trials as TopicRecurrenceTreatment OutcomeDrugs, Chinese Herballiu-jun-zi-tangFunctional dyspepsiaMeta-analysisRikkunshitoSystematic reviewWestern medicine

Identifiers

PMID32767596
PMCPMC7818190
OpenAlexW3047675767

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.