Evidence map›Paper›PMID 32768866›Full record

ArticleNeurobiology of aging2020

Role of Kalirin and mouse strain in retention of spatial memory training in an Alzheimer's disease model mouse line.

Lillian Russo-Savage, Vishwanatha K S Rao, Betty A Eipper, Richard E Mains

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lillian Russo-SavageDepartment of Neuroscience, University of Connecticut Health Center, Farmington, CT, USA.
Vishwanatha K S RaoDepartment of Neuroscience, University of Connecticut Health Center, Farmington, CT, USA.
Betty A EipperDepartment of Neuroscience, University of Connecticut Health Center, Farmington, CT, USA; Department of Molecular Biology & Biochemistry, University of Connecticut Health Center, Farmington, CT, USA.
Richard E MainsDepartment of Neuroscience, University of Connecticut Health Center, Farmington, CT, USA. Electronic address: mains@uchc.edu.
UConn Health · US

Funding

CELL BIOLOGY OF BIOACTIVE PEPTIDE SECRETIONR01DK032948 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI EIPPER, ELIZABETH ANNE, MAINS, RICHARD E · 1986 to 2019
$7.3M
NIDDK NIH HHS R01 DK032948
6 · The paper itself

Abstract

Nontransgenic and 3xTG transgenic mice, which express mutant transgenes encoding human amyloid precursor protein (hAPP) along with Alzheimer's disease-associated versions of hTau and a presenilin mutation, acquired the Barnes Maze escape task equivalently at 3-9 months of age. Although nontransgenics retested at 6 and 9 months acquired the escape task more quickly than naïve mice, 3xTG mice did not. Deficits in Kalirin, a multidomain protein scaffold and guanine nucleotide exchange factor that regulates dendritic spines, has been proposed as a contributor to the cognitive decline observed in Alzheimer's disease. To test whether deficits in Kalirin might amplify deficits in 3xTG mice, mice heterozygous/hemizygous for Kalirin and the 3xTG transgenes were generated. Mouse strain, age and sex affected cortical expression of key proteins. hAPP levels in 3xTG mice increased total APP levels at all ages. Kalirin expression showed strong sex-dependent expression in C57 but not B6129 mice. Decreasing Kalirin levels to half had no effect on Barnes Maze task acquisition or retraining in 3xTG hemizygous mice.

Indexed as

AgingAlzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsCerebral CortexCognitive DysfunctionDisease Models, AnimalFemaleGene ExpressionGuanine Nucleotide Exchange FactorsHemizygoteHeterozygoteMaleMaze LearningMice, Inbred C57BLMice, TransgenicAmyloid beta-Protein PrecursorGuanine Nucleotide Exchange FactorsKALRN protein, humanProtein Serine-Threonine Kinases3xTG-ADBarnes mazePeptidePeptidylglycine alpha-amidating monooxygenaseProhormone convertaseRotarodWestern analysis

Identifiers

PMID32768866
PMCPMC7609455
OpenAlexW3042968967

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.