Trial reportThe Journal of infectious diseases2021
The Impact of Moderate or High-Intensity Combined Exercise on Systemic Inflammation Among Older Persons With and Without HIV.
Trial report in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02404792 (Exercise for Healthy Aging), which is not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exercise for Healthy Aging: The Impact of HIV and Aging on Physical Function and the Somatopause
Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Chronotropic Incompetence Among People With HIV Improves With Exercise Training in the Exercise for Healthy Aging Study.The Journal of infectious diseases · 2024Trial
- Prevalence and clinical correlates of frailty among adults with HIV infection and unhealthy alcohol or drug use.AIDS (London, England) · 2026Article
- QR Code-Enabled Self-Access Lifestyle Education in Older People Living With HIV: Pragmatic Pilot Quasi-Experimental Pretest-Posttest Implementation Study.Journal of medical Internet research · 2026Article
- Current perspectives and emerging directions in research and practice: highlights from the 15th Annual International Workshop on Aging and HIV.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Feasibility of high-intensity interval training in older adults with HIV and co-occurring hypertension.Pilot and feasibility studies · 2026Article
- Randomized Clinical Trial of High Intensity Exercise in People with HIV: Effects on Muscle Composition and Inflammation.Journal of acquired immune deficiency syndromes (1999) · 2025Article
- Examining the Heterogeneity of Exercise Response Among Sedentary Older Adults: A Descriptive Analysis.Journal of aging research · 2025Article
- Exercise to Prevent Accelerated Vascular Aging in People Living With HIV.Circulation research · 2024Review
- Implications of vascular depression for successful cognitive aging in HIV Disease.Journal of neurovirology · 2024Article
- Exercise: a non-drug strategy of NK cell activation.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024Review
- Chronotropic Incompetence among People with HIV Improves with Exercise Training in the Exercise for Healthy Aging Study.medRxiv : the preprint server for health sciences · 2023Article
- Finding the priority and cluster of inflammatory biomarkers for infectious preterm birth: a systematic review.Journal of inflammation (London, England) · 2023Review
- An aerobic exercise intervention to improve metabolic health among people living with HIV with at-risk alcohol use: the ALIVE-Ex research study protocol.AIDS research and therapy · 2023Article
- Exercise Training to Improve Brain Health in Older People Living With HIV: Study Protocol for a Randomized Controlled Trial.JMIR research protocols · 2023Article
- Diet, sleep, and exercise in inflammatory skin diseases.Our dermatology online · 2023Article
- Biological ageing with HIV infection: evaluating the geroscience hypothesis.The lancet. Healthy longevity · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWe investigated whether higher-intensity exercise provided greater decrease in markers of inflammation, and whether responses differed by HIV serostatus.
methodsPeople with HIV (PWH; n = 32) and controls (n = 37) aged 50-75 years completed 12 weeks moderate-intensity exercise, then were randomized to moderate- or high-intensity exercise for 12 additional weeks (n = 27 and 29, respectively). Inflammation biomarkers were measured at 0, 12, 24 weeks. Mixed and multiple regression models were adjusted for baseline inflammation, age, and body mass index.
resultsBaseline tumor necrosis factor-α (TNF-α), soluble TNF receptor 2 (sTNFR2), and soluble CD14 (sCD14) were significantly higher among PWH than controls (P < .04). From week 0-12, changes in interleukin-6 (IL-6), TNF-α, and sTNFR1 were not significantly different by HIV serostatus. We found no significant interaction between HIV serostatus/exercise intensity on week 12-24 changes in IL-6, TNF-α, and sTNFR1. Among high-intensity exercisers, PWH and controls had significant increases in sCD14 (P ≤ .003), controls significant increases in IL-10 (P = .01), and PWH nonsignificant decrease in highly sensitive C-reactive protein (P = .07). Other markers were not significantly different by serostatus or intensity.
conclusionsModerate and high-intensity exercise elicited similar effects on inflammation among PWH and controls, with additional beneficial effects seen among high-intensity exercisers. Increase in sCD14 and attenuated IL-10 increase (PWH only) merit further study. CLINICAL TRIALS REGISTRATION: NCT02404792.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.