Evidence map›Paper›PMID 32781858›Full record

ArticleInhalation toxicology2020

Differential lung inflammation and injury with tobacco smoke exposure in Wistar Kyoto and spontaneously hypertensive rats.

Alexa K Pham, Ching-Wen Wu, Xing Qiu, Jingyi Xu, Suzette Smiley-Jewell, Dale Uyeminami, Priya Upadhyay, Dewei Zhao, Kent E Pinkerton

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inhalation toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Animal models and mechanisms of tobacco smoke-induced chronic obstructive pulmonary disease (COPD).Journal of toxicology and environmental health. Part B, Critical reviews · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Alexa K PhamCenter for Health and the Environment, University of California, Davis, CA, USA.
Ching-Wen WuCenter for Health and the Environment, University of California, Davis, CA, USA.ORCID 0000-0003-4302-9295
Xing QiuDepartment of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
Jingyi XuDepartment of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
Suzette Smiley-JewellCenter for Health and the Environment, University of California, Davis, CA, USA.
Dale UyeminamiCenter for Health and the Environment, University of California, Davis, CA, USA.
Priya UpadhyayCenter for Health and the Environment, University of California, Davis, CA, USA.
Dewei ZhaoDepartment of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
Kent E PinkertonCenter for Health and the Environment, University of California, Davis, CA, USA.ORCID 0000-0001-9047-0353
University of California, Davis · USAffiliated Zhongshan Hospital of Dalian University · CN

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
ZONA PELLUCIDA PEPTIDES AS IMMUNOCONTRACEPTIVE ANTIGENSP51RR000169 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI FUJII, GARY · 1985 to 2011
$126.2M
TRAINING IN COMPARATIVE LUNG BIOLOGY AND MEDICINET32HL007013 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI Elena Goncharova, Nicholas J. KENYON · 1985 to 2026
$10.1M
NIEHS Center for Health Effects of AgrochemicalsP30ES005707 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI PLOPPER, CHARLES GEORGE · 1992 to 2006
$9.9M
Environmental Influences on Perinatal Lung DevelopmentR01ES011634 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI PINKERTON, KENT ED · 2002 to 2006
$1.5M
NCRR NIH HHS P51 RR000169NHLBI NIH HHS T32 HL007013NIEHS NIH HHS P30 ES005707NIEHS NIH HHS R01 ES011634NIH HHS P51 OD011107
6 · The paper itself

Abstract

objectiveChronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide and has been associated with periods of intense lung inflammation. The objective of this study was to characterize whether similar rat strains, possessing different genetic predispositions, might play a role in exacerbating the pathophysiology of COPD-like cellular and structural changes with progressive 12-week exposure to tobacco smoke (TS). Normotensive Wistar Kyoto (WKY) and spontaneously hypertensive (SH) rats were compared. MATERIALS AND

methodsWKY and SH rats were exposed to filtered air or to tobacco smoke at a particulate concentration of 80 mg/m RESULTS AND DISCUSSION: With progressive exposure, TS-exposed SH rats demonstrated significant airspace enlargement, mucin production, and lung inflammation compared to their FA control and TS-matched WKY rats. Moreover, SH rats also demonstrated increased expression of the M1 marker in alveolar macrophages compared to FA control, as well as the M2 marker compared to controls and TS-exposed WKY rats.

conclusionThe progressive tobacco smoke exposure contributes to persistent lung injury and inflammation that can be significantly enhanced by rat strain susceptibility in the genesis of COPD.

Indexed as

AnimalsBronchiolitisChemokine CCL2Chemokine CXCL1InflammationLungLung InjuryMacrophagesMaleRats, Inbred SHRRats, Inbred WKYSmokeTobacco Smoke PollutionCcl2 protein, ratChemokine CCL2Chemokine CXCL1Cxcl1 protein, ratSmokeTobacco Smoke Pollutionchronic obstructive pulmonary diseasemacrophagespontaneously hypertensive ratsTobacco smokeWistar Kyoto rats

Identifiers

PMID32781858
PMCPMC8034838
OpenAlexW3048942246

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.