Evidence map›Paper›PMID 32791046›Full record

ReviewThe lancet. HIV2020

Haemopoietic cell transplantation in patients living with HIV.

Richard F Ambinder, Adam A Capoferri, Christine M Durand

Abstract readReview
In one paragraph

Review in The lancet. HIV, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Advanced Therapies for Human Immunodeficiency Virus.Medical sciences (Basel, Switzerland) · 2024
    Review
  10. Treating Cancer in People With HIV.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Role of the pharmacist caring for people at risk of or living with HIV in Canada.Canadian pharmacists journal : CPJ = Revue des pharmaciens du Canada : RPC
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Richard F AmbinderJohns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: rambind1@jhmi.edu.
Adam A CapoferriDepartment of Microbiology and Immunology, Georgetown University, Washington, DC, USA.
Christine M DurandJohns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

Consortium for Advancing Management and Prevention of Cancer in People with HIVUM1CA121947 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Joseph A. Sparano · 2015 to 2026
$253.7M
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Anna Palmer Durbin · 2012 to 2026
$67.0M
TUMOR VACCINESP01CA015396 · NCI · JOHNS HOPKINS UNIVERSITY · PI HESS, ALLAN D · 1985 to 2016
$38.1M
Targeting MRDP01CA225618 · NCI · JOHNS HOPKINS UNIVERSITY · PI Lukasz Pawel Gondek · 2019 to 2026
$15.1M
Optimal Antiretroviral Therapy During Bone Marrow Transplant in HIV-1 InfectionK23CA177321 · NCI · JOHNS HOPKINS UNIVERSITY · PI DURAND, CHRISTINE MARIE · 2014 to 2018
$808k
NCI NIH HHS K23 CA177321NCI NIH HHS K23CA177321–01A1NCI NIH HHS P01 CA015396NCI NIH HHS P01 CA225618NCI NIH HHS P01 CA225618–01A1NCI NIH HHS UM1 CA121947NIAID NIH HHS P30 AI094189
6 · The paper itself

Abstract

Haemopoietic cell transplantation is established as a standard treatment approach for people living with HIV who have haematological malignancies with poor prognosis. Studies with autologous and allogeneic haemopoietic cell transplantation suggest that HIV status does not adversely affect outcomes, provided that there is adequate infection prophylaxis. Attention to possible drug-drug interactions is important. Allogeneic haemopoietic cell transplantation substantially reduces the long-term HIV reservoir when complete donor chimerism is established. When transplants from CCR5Δ32 homozygous donors are used, HIV cure is possible.

Indexed as

Hematopoietic Stem Cell TransplantationAntiretroviral Therapy, Highly ActiveDisease ManagementDisease SusceptibilityGenetic Predisposition to DiseaseGraft vs Host DiseaseHematologic NeoplasmsHIV InfectionsHomozygoteHumansMutationReceptors, CCR5Transplantation, AutologousTransplantation, HomologousTreatment OutcomeCCR5 protein, humanReceptors, CCR5

Identifiers

PMID32791046
PMCPMC8276629

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.