Evidence map›Paper›PMID 32793202›Full record

SynthesisFrontiers in immunology2020

Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythematosus (SLE): A Systematic Review.

Md Asiful Islam, Shahad Saif Khandker, Przemysław J Kotyla, Rosline Hassan

2 registry-linked trialsOpen access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 69 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 7 pooled it
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07071233 nacompletednot on this mapstarted 2024, after this paper: background citation

Efficacy of Vitamin C Supplementation on Serum TNF-α Levels and Disease Activity in Systemic Lupus Erythematosus Patients

TypeinterventionalSponsorUniversitas SriwijayaRan2024 to 2024Enrolled38ConditionsSystemic Lupus Erythematosus (SLE)ArmsVitamin C, Placebo
NCT07555626 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effects of a Mediterranean Diet-Based Nutritional Intervention on Gut Microbiota, Disease Activity, and Nutritional Status in Children With Systemic Lupus Erythematosus

TypeinterventionalSponsorTC Erciyes UniversityRan2026 to 2029Enrolled60ConditionsSystemic Lupus Erythematosus (SLE)ArmsMediterranean Diet-Based Individual Nutrition Counseling
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 7 syntheses or guidelines pooled it, 109 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Oral Manifestations of Systemic Lupus Erythematosus: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
  5. Diet and Systemic Lupus Erythematosus (SLE): From Supplementation to Intervention.International journal of environmental research and public health · 2022
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
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  20. Review

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Md Asiful IslamDepartment of Haematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
Shahad Saif KhandkerDepartment of Biochemistry and Molecular Biology, Jahangirnagar University, Dhaka, Bangladesh.
Przemysław J KotylaDepartment of Internal Medicine, Rheumatology and Clinical Immunology, Medical Faculty in Katowice, Medical University of Silesia, Katowice, Poland.
Rosline HassanDepartment of Haematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
Universiti Sains Malaysia · MYJahangirnagar University · BDMedical University of Silesia · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple organ involvement, including the skin, joints, kidneys, lungs, central nervous system and the haematopoietic system, with a large number of complications. Despite years of study, the etiology of SLE remains unclear; thus, safe and specifically targeted therapies are lacking. In the last 20 years, researchers have explored the potential of nutritional factors on SLE and have suggested complementary treatment options through diet. This study systematically reviews and evaluates the clinical and preclinical scientific evidence of diet and dietary supplementation that either alleviate or exacerbate the symptoms of SLE. For this review, a systematic literature search was conducted using PubMed, Scopus and Google Scholar databases only for articles written in the English language. Based on the currently published literature, it was observed that a low-calorie and low-protein diet with high contents of fiber, polyunsaturated fatty acids, vitamins, minerals and polyphenols contain sufficient potential macronutrients and micronutrients to regulate the activity of the overall disease by modulating the inflammation and immune functions of SLE.

Indexed as

Dietary SupplementsDiet TherapyAnimalsDietFatty Acids, UnsaturatedHumansImmunomodulationLupus Erythematosus, SystemicMineralsPolyphenolsFatty Acids, UnsaturatedMineralsPolyphenolsautoimmune diseasesdietmineralsnutrientspolyphenolspolyunsaturated fatty acidssystemic lupus erythematosus (SLE)vitamins

Identifiers

PMID32793202
PMCPMC7387408
OpenAlexW3044931877

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.