Evidence map›Paper›PMID 32796038›Full record

ReviewThe Journal of biological chemistry2020

Structure-guided approaches to targeting stress responses in human fungal pathogens.

Emmanuelle V LeBlanc, Elizabeth J Polvi, Amanda O Veri, Gilbert G Privé, Leah E Cowen

Open access · hybridAbstract readReview
In one paragraph

Review in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Molecular Dynamics Insights intoInternational journal of molecular sciences · 2026
    Article
  3. OvercomingFrontiers in antibiotics · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogenProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Emmanuelle V LeBlancDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-4278-0984
Elizabeth J PolviDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-7827-826X
Amanda O VeriDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-1764-8439
Gilbert G PrivéDepartments of Medical Biophysics and Biochemistry, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-0712-4319
Leah E CowenDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada leah.cowen@utoronto.ca.ORCID 0000-0001-5797-0110
University of Toronto · CA

Funding

Targeting Hsp90 in cryptococcal fungal pathogenesisR01AI120958 · NIAID · UNIVERSITY OF TORONTO · PI BROWN, LAUREN ELAINE, COWEN, LEAH ELIZABETH · 2016 to 2019
$3.2M
CIHR FDN-154288NIAID NIH HHS R01 AI120958
6 · The paper itself

Abstract

Fungi inhabit extraordinarily diverse ecological niches, including the human body. Invasive fungal infections have a devastating impact on human health worldwide, killing ∼1.5 million individuals annually. The majority of these deaths are attributable to species of

Indexed as

Antifungal AgentsBinding SitesCalcineurinCandidaDrug DesignFungal ProteinsHSP90 Heat-Shock ProteinsHumansMolecular Dynamics SimulationMycosesAntifungal AgentsCalcineurinFungal ProteinsHSP90 Heat-Shock Proteinsantibioticsantifungalantifungal drug developmentcalcineurindrug designfungiheat shock protein 90 (Hsp90)microbial pathogenesismicrobiologymolecular chaperoneRasstress responsestructural biologystructure-guided drug design

Identifiers

PMID32796038
PMCPMC7573264
OpenAlexW3049399022

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.