Evidence map›Paper›PMID 32797398›Full record

SynthesisBrain imaging and behavior2021

Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group.

Alexander Olsen, Talin Babikian, Erin D Bigler, Karen Caeyenberghs, Virginia Conde, Kristen Dams-O'Connor, Ekaterina Dobryakova, Helen Genova, Jordan Grafman, Asta K Håberg and 27 more

Open access · hybridAbstract readMeta-AnalysisConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  10. ENIGMA-Meditation: Worldwide Consortium for Neuroscientific Investigations of Meditation Practices.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 20 institutions in 8 countries.

Alexander OlsenDepartment of Psychology, Norwegian University of Science and Technology, 7491, Trondheim, Norway. alexander.olsen@ntnu.no.ORCID http://orcid.org/0000-0001-8691-3860
Talin BabikianDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA.
Erin D BiglerDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Karen CaeyenberghsCognitive Neuroscience Unit, School of Psychology, Deakin University, Burwood, Australia.
Virginia CondeDepartment of Psychology, Norwegian University of Science and Technology, 7491, Trondheim, Norway.
Kristen Dams-O'ConnorDepartment of Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ekaterina DobryakovaCenter for Traumatic Brain Injury, Kessler Foundation, East Hanover, NJ, USA.
Helen GenovaCenter for Traumatic Brain Injury, Kessler Foundation, East Hanover, NJ, USA.
Jordan GrafmanCognitive Neuroscience Laboratory, Shirley Ryan AbilityLab, Chicago, IL, USA.
Asta K HåbergDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Ingrid HegglandSection for Collections and Digital Services, NTNU University Library, Norwegian University of Science and Technology, Trondheim, Norway.
Torgeir HellstrømDepartment of Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway.
Cooper B HodgesDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Andrei IrimiaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Ruchira M JhaDepartments of Critical Care Medicine, Neurology, Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Paula K JohnsonDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Vassilis E KoliatsosDepartments of Pathology(Neuropathology), Neurology, and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Harvey LevinH. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.
Lucia M LiC3NL, Imperial College London, London, UK.
Hannah M LindseyDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Abigail LivnyDepartment of Diagnostic Imaging, Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel.
Marianne LøvstadSunnaas Rehabilitation Hospital, Nesodden, Norway.
John MedagliaDepartment of Psychology, Drexel University, Philadelphia, PA, USA.
David K MenonDivision of Anaesthesia, University of Cambridge, Cambridge, UK.
Stefania MondelloDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.
Martin M MontiDepartment of Psychology, University of California Los Angeles, Los Angeles, CA, USA.
Virginia F J NewcombeDivision of Anaesthesia, University of Cambridge, Cambridge, UK.
Agustin PetroniDepartment of Psychology, Norwegian University of Science and Technology, 7491, Trondheim, Norway.
Jennie PonsfordTurner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Australia.
David SharpDepartment of Brain Sciences, Imperial College London, London, UK.
Gershon SpitzTurner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Australia.
Lars T WestlyeDepartment of Psychology, University of Oslo, Oslo, Norway.
Paul M ThompsonImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
Emily L DennisDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
David F TateDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Elisabeth A WildeDepartment of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Frank G HillaryDepartment of Neurology, Hershey Medical Center, State College, PA, USA. fhillary@psu.edu.
Norwegian University of Science and Technology · NOBrigham Young University · USOslo University Hospital · NOUniversity of Cambridge · GBUniversity of Utah · USBaylor College of Medicine · USDeakin University · AUDrexel University · USEpworth Hospital · AUIcahn School of Medicine at Mount Sinai · USImperial College London · GBJohns Hopkins University · USKessler Foundation · USLAC+USC Medical Center · USMichael E. DeBakey VA Medical Center · USMonash University · AUNorthwestern University · USPenn State Milton S. Hershey Medical Center · USRutgers, The State University of New Jersey · USSheba Medical Center · IL

Funding

TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M, TOGA, ARTHUR W · 2012 to 2022
$14.1M
The Late Effects of TBI (LETBI) Study: Injury Patterns and Biological Markers of Post-Traumatic NeurodegenerationRF1NS115268 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Kristen Dams-O'Connor · 2019 to 2026
$10.3M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Neuropathology of CTE and Delayed Effects of TBI: Toward In-Vivo DiagnosticsU01NS086625 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAMS-O'CONNOR, KRISTEN · 2014 to 2017
$6.1M
Trauma and Genomics Modulate Brain Structure across Common Psychiatric DisordersR01MH111671 · NIMH · DUKE UNIVERSITY · PI MARK W LOGUE, RAJENDRA A MOREY · 2017 to 2026
$4.4M
Contributions of spared brain structures and connections to aphasia recoveryR01DC014960 · NIDCD · GEORGETOWN UNIVERSITY · PI TURKELTAUB, PETER ETHAN · 2017 to 2021
$4.0M
Transcranial Magnetic Stimulation for Aphasia: Efficacy and Neural BasisR01DC016800 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI COSLETT, H BRANCH · 2018 to 2022
$3.3M
ENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMAR01MH116147 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2021
$2.5M
Dynamic Network Neuroscience and Control Theory: Toward Interventions for Cognitive Control DysfunctionDP5OD021352 · OD · UNIVERSITY OF PENNSYLVANIA · PI MEDAGLIA, JOHN · 2015 to 2019
$2.0M
Effects of blood-brain barrier disruption upon white matter connectivity subsequent to traumatic brain injuryR01NS100973 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI IRIMIA, ANDREI · 2017 to 2021
$1.6M
Translational assessment of sulfonylurea receptor-1 as a biomarker and therapeutic target for cerebral edema in traumatic brain injuryK23NS101036 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JHA, RUCHIRA MENKA · 2017 to 2021
$944k
ENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683k
CSRD VA 1Department of Health II-LB-0715-20006Department of Health NIHR-RP-011-048NIA NIH HHS R56 AG058854NIBIB NIH HHS P41 EB015922NIBIB NIH HHS U54 EB020403NIDCD NIH HHS R01 DC014960NIDCD NIH HHS R01 DC016800NIH HHS DP5 OD021352NIMH NIH HHS R01 MH111671NIMH NIH HHS R01 MH116147NINDS NIH HHS K23 NS101036NINDS NIH HHS K99 NS096116NINDS NIH HHS R01 NS100973NINDS NIH HHS RF1 NS115268NINDS NIH HHS U01 NS086625
6 · The paper itself

Abstract

The global burden of mortality and morbidity caused by traumatic brain injury (TBI) is significant, and the heterogeneity of TBI patients and the relatively small sample sizes of most current neuroimaging studies is a major challenge for scientific advances and clinical translation. The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Adult moderate/severe TBI (AMS-TBI) working group aims to be a driving force for new discoveries in AMS-TBI by providing researchers world-wide with an effective framework and platform for large-scale cross-border collaboration and data sharing. Based on the principles of transparency, rigor, reproducibility and collaboration, we will facilitate the development and dissemination of multiscale and big data analysis pipelines for harmonized analyses in AMS-TBI using structural and functional neuroimaging in combination with non-imaging biomarkers, genetics, as well as clinical and behavioral measures. Ultimately, we will offer investigators an unprecedented opportunity to test important hypotheses about recovery and morbidity in AMS-TBI by taking advantage of our robust methods for large-scale neuroimaging data analysis. In this consensus statement we outline the working group's short-term, intermediate, and long-term goals.

Indexed as

Brain Injuries, TraumaticMagnetic Resonance ImagingAdultBrainHumansNeuroimagingReproducibility of ResultsBrain injuryENIGMANeurodegenerationOpen ScienceRadiologyRehabilitation

Identifiers

PMID32797398
PMCPMC8032647
OpenAlexW3049594523

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.