ArticleBiological psychiatry2021
Estimating the Heritability of Developmental Change in Neural Connectivity, and Its Association With Changing Symptoms of Attention-Deficit/Hyperactivity Disorder.
Article in Biological psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Combined family-based association and linkage analyses in families affected by attention-deficit hyperactivity disorder.Human genetics · 2026Pooled it
- Developmental trajectories of glutamate and the variable clinical course of ADHD in youth.Translational psychiatry · 2026Article
- Childhood white matter morphology and longitudinal change in symptoms of attention-deficit/hyperactivity disorder.Developmental medicine and child neurology · 2026Article
- White matter microstructure changes across the lifespan: a meta-analysis of longitudinal diffusion MRI studies.bioRxiv : the preprint server for biology · 2025Article
- Cortical structural and functional coupling during development and implications for attention deficit hyperactivity disorder.Translational psychiatry · 2023Article
- White matter microstructural variability linked to differential attentional skills and impulsive behavior in a pediatric population.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Neuro-ophthalmologic and blood biomarker responses in ADHD following subconcussive head impacts: a case-control trial.Frontiers in psychiatry · 2023Article
- Evidence from "big data" for the default-mode hypothesis of ADHD: a mega-analysis of multiple large samples.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- The potential shared brain functional alterations between adults with ADHD and children with ADHD co-occurred with disruptive behaviors.Child and adolescent psychiatry and mental health · 2022Article
- Intrinsic Functional Connectivity in the Default Mode Network Differentiates the Combined and Inattentive Attention Deficit Hyperactivity Disorder Types.Frontiers in human neuroscience · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundTwin studies show that age-related change in symptoms of attention-deficit/hyperactivity disorder (ADHD) is heritable. However, we do not know the heritability of the development of the neural substrates underlying the disorder. Here, we estimated the heritability of developmental change in white matter tracts and the brain's intrinsic functional connectivity using longitudinal data. We further determined associations with change in ADHD symptoms.
methodsThe study reports on 288 children, which included 127 siblings, 19 cousins, and 142 singletons; 150 (52%) had a diagnosis of ADHD (determined by clinician interview with parent); 188 were male. All had two clinical assessments (overall baseline mean age: 9.4 ± 2.4 years; follow-up: 12.5 ± 2.6 years). Diffusion tensor imaging estimated microstructural properties of white matter tracts on 252 participants. Resting-state functional magnetic resonance imaging estimated intrinsic connectivity within and between major brain networks on 226 participants. Total additive genetic heritability (h
resultsSignificant heritability was found for the rates of change of 6 white matter tract microstructural properties and for change in the connectivity between the ventral attention network and both the cognitive control and dorsal attention networks. Change in hyperactivity-impulsivity was associated with heritable change in white matter tracts metrics and change in the connectivity between the ventral attention and cognitive networks.
conclusionsThe relatively small number of heritable, ADHD-associated developmental neural phenotypes can serve as phenotypes for future gene discovery and understanding.
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