ArticleNeurosurgical review2021
Effect of bifurcation in the hemodynamic changes and rupture risk of small intracranial aneurysm.
Article in Neurosurgical review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- A meta-analysis on the prevalence of anxiety and depression in patients with unruptured intracranial aneurysms: exposing critical treatment gaps.Neurosurgical review · 2022Pooled it
- An explainable artificial intelligence framework for clinical decision support in stroke discharge planning.PloS one · 2026Article
- Target Gene-Based Association Study of High Mobility Group Box Protein 1 in Intracranial Aneurysms in Koreans.Brain sciences · 2024Article
- Effect of Bile on Hemodynamics and Blood Micro-Rheological Parameters in Experimental Models of Bilhemia.Metabolites · 2024Article
- Overlapping Stent Treatment for Ruptured Dissecting Aneurysms in Posterior Circulation.Brain sciences · 2023Article
- Selection of Bifurcated Grafts' Dimensions during Aorto-Iliac Vascular Reconstruction Based on Their Hemodynamic Performance.Bioengineering (Basel, Switzerland) · 2023Article
- Morphology and Hemodynamics of Cerebral Arteries and Aneurysms in a Rare Pair of Monozygotic Twins.Diagnostics (Basel, Switzerland) · 2023Article
- Assessing the risk of intracranial aneurysm rupture using computational fluid dynamics: a pilot study.Frontiers in neurology · 2023Article
- Flow Diverter Devices in the Treatment of Anterior Communicating Artery Region Aneurysms: Would the Regional Anatomy and the Aneurysm Location Affect the Outcomes?Brain sciences · 2022Article
- The Role of Bypass Surgery for the Management of Complex Intracranial Aneurysms in the Anterior Circulation in the Flow-Diverter Era: A Single-Center Series.Brain sciences · 2022Article
- Incidence rate and predictors of recurrent aneurysms after clipping: long-term follow-up study of survivors of subarachnoid hemorrhage.Neurosurgical review · 2022Article
- Hemodynamics and Tissue Optical Properties in Bimodal Infarctions Induced by Middle Cerebral Artery Occlusion.International journal of molecular sciences · 2022Article
- Intrasaccular Flow Disruptor-Assisted Coiling of Intracranial Aneurysms Using the Novel Contour Neurovascular Systems and NEQSTENT: A Single-Center Safety and Feasibility Study.Brain sciences · 2022Article
- Long-Lasting Unruptured Large Intracranial Aneurysm in Bilateral Moyamoya Disease: Case Report.Case reports in neurological medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of bifurcations is prominent in the intracranial aneurysm (IA) evaluation, and there are many contradictions and complexities in the rupture risk of small IA. Therefore, in the present study, the effect of bifurcation on the manner of hemodynamic changes and the rupture risk of the small middle cerebral artery (MCA) aneurysm is investigated. 3D anatomical models of the MCAs of 21 healthy subjects, 19 patients/IA/bifurcation, and 19 patients/IA were generated, and the models were analyzed by the computational fluid dynamic (CFD) analysis. The presence of bifurcation in the pathway of the blood flow in the parent artery of healthy subjects has reduced the maximum velocity, flow rate, and wall shear stress (WSS) by 25.8%, 38.6%, and 11.1%, respectively. The bifurcation decreased the maximum velocity and flow rate in the neck and sac of the aneurysm by 1.65~2.1 times, respectively. It increased the maximum WSS, and phase lag between the WSS graph of healthy subjects and patients by 12.8%~13.9% and 10.2%~40.4%, respectively. The effect of bifurcation on the Womersley number change in the aneurysm was insignificant, and the blood flow was in the laminar flow condition in all samples. The results also showed bifurcation increased the phase lag between the flow rate and pressure gradient graphs up to approximately 1.5 times. The rupture prediction index for patients/IA/bifurcation and patients/IA was 62.1%(CV = 4.1) and 51.8%(CV = 4.4), respectively. Thus, in equal conditions, the presence of bifurcation increased the probability of the rupture of the aneurysm by 19.9%.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.