Evidence map›Paper›PMID 32815768›Full record

ArticleChannels (Austin, Tex.)2020

Calmodulin binds to the N-terminal domain of the cardiac sodium channel Na

Zizun Wang, Sarah H Vermij, Valentin Sottas, Anna Shestak, Daniela Ross-Kaschitza, Elena V Zaklyazminskaya, Andy Hudmon, Geoffrey S Pitt, Jean-Sébastien Rougier, Hugues Abriel

Open access · goldAbstract readCase Reports
In one paragraph

Article in Channels (Austin, Tex.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Feedback contributions to excitation-contraction coupling in native functioning striated muscle.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  3. Article
  4. Article
  5. Article
  6. Dominant negative effects of SCN5A missense variants.Genetics in medicine : official journal of the American College of Medical Genetics · 2022
    Article
  7. Review
  8. Review
  9. Article
  10. NaStructure (London, England : 1993) · 2021
    Article
  11. Observational
  12. Review
  13. Review
  14. Calmodulin Interactions with Voltage-Gated Sodium Channels.International journal of molecular sciences · 2021
    Review
  15. Review
  16. Elementary mechanisms of calmodulin regulation of NaProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  17. Article
  18. Frontiers in physiology · 2021
    Article
  19. Article
  20. NovelFrontiers in cardiovascular medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Zizun WangInstitute of Biochemistry and Molecular Medicine, University of Bern , Bern, Switzerland.ORCID 0000-0002-8889-6416
Sarah H VermijInstitute of Biochemistry and Molecular Medicine, University of Bern , Bern, Switzerland.ORCID 0000-0002-6419-6159
Valentin SottasInstitute of Biochemistry and Molecular Medicine, University of Bern , Bern, Switzerland.
Anna ShestakIbex, Petrovskiy Russian Scientific Center of Surgery , Moscow, Russia.ORCID 0000-0002-4596-8950
Daniela Ross-KaschitzaInstitute of Biochemistry and Molecular Medicine, University of Bern , Bern, Switzerland.ORCID 0000-0003-1367-0671
Elena V ZaklyazminskayaIbex, Petrovskiy Russian Scientific Center of Surgery , Moscow, Russia.ORCID 0000-0002-6244-9546
Andy HudmonDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University , West Lafayette, Indiana, USA.ORCID 0000-0002-5039-6803
Geoffrey S PittCardiovascular Research Institute, Weill Cornell Medical College , New York, USA.ORCID 0000-0003-2246-0289
Jean-Sébastien RougierInstitute of Biochemistry and Molecular Medicine, University of Bern , Bern, Switzerland.ORCID 0000-0002-8710-0260
Hugues AbrielInstitute of Biochemistry and Molecular Medicine, University of Bern , Bern, Switzerland.ORCID 0000-0003-0465-5138
University of Bern · CHRussian Scientific Center of Surgery · RUCornell University · USPurdue University West Lafayette · US

Funding

Molecular and circuit defects underlying different SCN2A mutations and ASDsR01MH118934 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI PITT, GEOFFREY S · 2019 to 2023
$3.2M
Multidisciplinary Research Training in Cardiovascular DiseaseT32HL160520 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Geoffrey S Pitt, Jonathan W. Weinsaft · 2022 to 2026
$2.0M
NHLBI NIH HHS T32 HL160520NIMH NIH HHS R01 MH118934
6 · The paper itself

Abstract

The cardiac voltage-gated sodium channel Na

Indexed as

AnimalsBlotting, WesternBrugada SyndromeCalmodulinCell LineCells, CulturedElectrophoresis, Polyacrylamide GelElectrophysiologyExonsHumansMaleMiddle AgedNAV1.5 Voltage-Gated Sodium ChannelProtein BindingRatsYoung AdultCalmodulinNAV1.5 Voltage-Gated Sodium ChannelBrugada syndromeCalmodulindominant-negative effectNav1.5 N-terminal domainSCN5Asodium channels

Identifiers

PMID32815768
PMCPMC7515574
OpenAlexW3080335073

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.