Evidence map›Paper›PMID 32817554›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

A supergene-linked estrogen receptor drives alternative phenotypes in a polymorphic songbird.

Jennifer R Merritt, Kathleen E Grogan, Wendy M Zinzow-Kramer, Dan Sun, Eric A Ortlund, Soojin V Yi, Donna L Maney

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. The neural substrates of behavioral evolution: Divergent behaviors from conserved neurons.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Supergenes on steroids.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jennifer R MerrittDepartment of Psychology, Emory University, Atlanta, GA 30322; jrmerri@emory.edu.ORCID 0000-0002-1189-0454
Kathleen E GroganDepartment of Psychology, Emory University, Atlanta, GA 30322.ORCID 0000-0002-0112-1766
Wendy M Zinzow-KramerDepartment of Psychology, Emory University, Atlanta, GA 30322.ORCID 0000-0003-1469-5803
Dan SunSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.ORCID 0000-0003-2147-9308
Eric A OrtlundDepartment of Biochemistry, Emory University, Atlanta, GA 30322.ORCID 0000-0001-8855-3029
Soojin V YiSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332.ORCID 0000-0003-1497-1871
Donna L ManeyDepartment of Psychology, Emory University, Atlanta, GA 30322.ORCID 0000-0002-1006-2358

Funding

A Unique Natural Model for Studying the Mechanisms Underlying Social BehaviorR01MH082833 · NIMH · EMORY UNIVERSITY · PI MANEY, DONNA L · 2010 to 2021
$3.2M
Estrogen receptor alpha and social behavior: Drawing causal connections between genotype and phenotypeF31MH114509 · NIMH · EMORY UNIVERSITY · PI MERRITT, JENNIFER ROSE · 2018 to 2019
$90k
NIMH NIH HHS F31 MH114509NIMH NIH HHS R01 MH082833
6 · The paper itself

Abstract

Behavioral evolution relies on genetic changes, yet few behaviors can be traced to specific genetic sequences in vertebrates. Here we provide experimental evidence showing that differentiation of a single gene has contributed to the evolution of divergent behavioral phenotypes in the white-throated sparrow, a common backyard songbird. In this species, a series of chromosomal inversions has formed a supergene that segregates with an aggressive phenotype. The supergene has captured

Indexed as

AggressionAnimalsBehavior, AnimalChromosome InversionEstrogen Receptor alphaEstrogensFemaleGenotypeMalePhenotypeReceptors, EstrogenSocial BehaviorSparrowsEstrogen Receptor alphaEstrogensReceptors, Estrogenchromosomal inversionsocial behaviorsongbird

Identifiers

PMID32817554
PMCPMC7474689

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.