Evidence map›Paper›PMID 32823402›Full record

ReviewIndian journal of ophthalmology2020

Systemic immunosuppressive therapies for uveitis in developing countries.

Hitesh Agrawal, Hien Doan, Brandon Pham, Amit Khosla, Manohar Babu, Peter McCluskey, Quan Dong Nguyen, Virender Sangwan, Subhakar Reddy, Sujata Sawhney and 1 more

Open access · diamondAbstract readReview
In one paragraph

Review in Indian journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Pathogenesis and current therapies for non-infectious uveitis.Clinical and experimental medicine · 2023
    Review
  10. Article
  11. SARS-CoV-2 vaccination and uveitis: Are they linked?Annals of medicine and surgery (2012) · 2022
    Review
  12. Exploring a New Era in Uveitis.Indian journal of ophthalmology · 2020
    Article
  13. Efficacy of azathioprine as a first-line therapy in new onset of acute Vogt-Koyanagi-Harada disease in the Indian population.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hitesh AgrawalL V Prasad Eye Institute, Hyderabad, Telangana, India.
Hien DoanByers Eye Institute, Palo Alto, CA, USA.
Brandon PhamByers Eye Institute, Palo Alto, CA, USA.
Amit KhoslaSir Ganga Ram Hospital, New Delhi, India.
Manohar BabuAravind Eye Institute, Salem, Tamil Nadu, India.
Peter McCluskeySave Sight Institute, Sydney NSW, Australia, USA.
Quan Dong NguyenByers Eye Institute, Palo Alto, CA, USA.
Virender SangwanDr Shroff Charity Eye Hospital, New Delhi, India.
Subhakar ReddyL V Prasad Eye Institute, Hyderabad, Telangana, India.
Sujata SawhneySir Ganga Ram Hospital, New Delhi, India.
Mudit TyagiL V Prasad Eye Institute, Hyderabad, Telangana, India.
L V Prasad Eye Institute · INSir Ganga Ram Hospital · INDr. Shroff’s Charity Eye Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are multiple approaches to inhibit inflammatory molecules and pathways in noninfectious uveitis. The cornerstone of local and systemic anti-inflammatory treatment is corticosteroid therapy. Corticosteroids remain the most potent and efficacious drugs for treating intraocular inflammation. However, their long-term use is limited by their medium- and long-term side effects, which are a major concern. The approach taken to limit corticosteroid side effects is to introduce steroid-sparing agents that suppress the inflammatory pathways and immune response differently than corticosteroids. There are several classes of such drugs that are affordable, effective, and generally well-tolerated. Relatively recently, an increasing range of biologic agents has become available to treat intraocular inflammation. However, the relatively expensive cost of these therapies limits their use in the developing world. This systemic review aimst to discuss the use of corticosteroids and different immunosuppressive regimens in the management of various uveitides.

Indexed as

Developing CountriesUveitisAdrenal Cortex HormonesHumansImmunosuppression TherapyImmunosuppressive AgentsAdrenal Cortex HormonesImmunosuppressive AgentsBiologicalscorticosteroidsimmunosuppressioninflammationnon infectious uveitis

Identifiers

PMID32823402
PMCPMC7690522
OpenAlexW3080322413

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.