Evidence map›Paper›PMID 32825245›Full record

ReviewInternational journal of molecular sciences2020

Roles of Proteoglycans and Glycosaminoglycans in Cancer Development and Progression.

Jinfen Wei, Meiling Hu, Kaitang Huang, Shudai Lin, Hongli Du

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 1 synthesis or guideline pooled it, 165 citations in OpenAlex.

  1. Pooled it
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  16. A novel prognostic and immune-related biomarkerTranslational cancer research · 2025
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jinfen WeiSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou 510640, China.
Meiling HuSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou 510640, China.
Kaitang HuangSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou 510640, China.
Shudai LinSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou 510640, China.
Hongli DuSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou 510640, China.
South China University of Technology · CN

Funding

Key R&D Program of Guangdong Province 2019B020226001National Key R&D Program of China 2018YFC0910201Science and the Technology Planning Project of Guangzhou 201704020176
6 · The paper itself

Abstract

The extracellular matrix (ECM) spatiotemporally controls cell fate; however, dysregulation of ECM remodeling can lead to tumorigenesis and cancer development by providing favorable conditions for tumor cells. Proteoglycans (PGs) and glycosaminoglycans (GAGs) are the major macromolecules composing ECM. They influence both cell behavior and matrix properties through direct and indirect interactions with various cytokines, growth factors, cell surface receptors, adhesion molecules, enzymes, and glycoproteins within the ECM. The classical features of PGs/GAGs play well-known roles in cancer angiogenesis, proliferation, invasion, and metastasis. Several lines of evidence suggest that PGs/GAGs critically affect broader aspects in cancer initiation and the progression process, including regulation of cell metabolism, serving as a sensor of ECM's mechanical properties, affecting immune supervision, and participating in therapeutic resistance to various forms of treatment. These functions may be implemented through the characteristics of PGs/GAGs as molecular bridges linking ECM and cells in cell-specific and context-specific manners within the tumor microenvironment (TME). In this review, we intend to present a comprehensive illustration of the ways in which PGs/GAGs participate in and regulate several aspects of tumorigenesis; we put forward a perspective regarding their effects as biomarkers or targets for diagnoses and therapeutic interventions.

Indexed as

Biomarkers, TumorCell ProliferationDrug Resistance, NeoplasmExtracellular MatrixFemaleGlycosaminoglycansHumansMaleNeoplasmsNeovascularization, PathologicProteoglycansTumor MicroenvironmentBiomarkers, TumorGlycosaminoglycansProteoglycanscancer progressionextracellular matrix remodelingglycosaminoglycansproteoglycanstumor microenvironment

Identifiers

PMID32825245
PMCPMC7504257
OpenAlexW3051479578

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.