Evidence map›Paper›PMID 32835763›Full record

ArticleToxicology and applied pharmacology2020

Triclosan disrupts immune cell function by depressing Ca

Suraj Sangroula, Alan Y Baez Vasquez, Prakash Raut, Bright Obeng, Juyoung K Shim, Grace D Bagley, Bailey E West, John E Burnell, Marissa S Kinney, Christian M Potts and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology and applied pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Pharmaceutical agent cetylpyridinium chloride inhibits immune mast cell function by interfering with calcium mobilization.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2023
    Article
  8. Article
  9. Triclosan: A Small Molecule with Controversial Roles.Antibiotics (Basel, Switzerland) · 2022
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Suraj SangroulaDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA.
Alan Y Baez VasquezDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA.
Prakash RautDepartment of Physics and Astronomy, University of Maine, Orono, ME, USA.
Bright ObengDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA.
Juyoung K ShimDepartment of Biology, University of Maine at Augusta, Augusta, ME, USA.
Grace D BagleyDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA.
Bailey E WestDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA.
John E BurnellDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA.
Marissa S KinneyDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA.
Christian M PottsDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA.
Sasha R WellerDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA; Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME, USA.
Joshua B KelleyDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA; Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME, USA.
Samuel T HessDepartment of Physics and Astronomy, University of Maine, Orono, ME, USA; Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME, USA.
Julie A GosseDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA; Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME, USA. Electronic address: Julie.gosse@maine.edu.
University of Maine · USUniversity of Maine at Augusta · US

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI JAMES A COFFMAN · 2012 to 2026
$60.0M
Mechanism of Triclosan Disruption of Mast Cell FunctionR15ES024593 · NIEHS · UNIVERSITY OF MAINE ORONO · PI GOSSE, JULIE ANN · 2014 to 2014
$421k
Mechanism of Association between Influenza Hemagglutinin and the Host Cell Actin CytoskeletonR15GM116002 · NIGMS · UNIVERSITY OF MAINE ORONO · PI HESS, SAMUEL T · 2015 to 2015
$337k
NIEHS NIH HHS R15 ES024593NIGMS NIH HHS P20 GM103423NIGMS NIH HHS R15 GM116002
6 · The paper itself

Abstract

Triclosan (TCS) is an antimicrobial agent that was effectively banned by the FDA from hand soaps in 2016, hospital soaps in 2017, and hand sanitizers in 2019; however, TCS can still be found in a few products. At consumer-relevant, non-cytotoxic doses, TCS inhibits the functions of both mitochondria and mast cells, a ubiquitous cell type. Via the store-operated Ca

Indexed as

Anti-Infective AgentsCalciumCalcium ChannelsCell DegranulationCell LineCell MembraneCytoplasmHumansHydrogen-Ion ConcentrationMast CellsMembrane PotentialsMitochondrial SwellingT-LymphocytesTriclosanAnti-Infective AgentsCalciumCalcium ChannelsTriclosanAcidificationGenetically encoded voltage indicatorMast cellStore-operated calcium entrySuper-resolution microscopyT cellTriclosan

Identifiers

PMID32835763
PMCPMC7566221
OpenAlexW3081189584

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.