Evidence map›Paper›PMID 32838613›Full record

ArticleRenal failure2020

Prediction models for acute kidney injury in patients with gastrointestinal cancers: a real-world study based on Bayesian networks.

Yang Li, Xiaohong Chen, Ziyan Shen, Yimei Wang, Jiachang Hu, Yunlu Zhang, Jiarui Xu, Xiaoqiang Ding

Open access · goldAbstract read
In one paragraph

Article in Renal failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

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  12. Prognostic factors for renal function deterioration during palliative first-line chemotherapy for metastatic colorectal cancer: a retrospective study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yang LiDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Xiaohong ChenDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Ziyan ShenDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Yimei WangDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Jiachang HuDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Yunlu ZhangDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Jiarui XuDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Xiaoqiang DingDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Fudan University · CNShanghai Blood Center · CNShanghai Institute of Hematology · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study attempts to establish a Bayesian networks (BNs) based model for inferring the risk of AKI in gastrointestinal cancer (GI) patients, and to compare its predictive capacity with other machine learning (ML) models.

methodsFrom 1 October 2014 to 30 September 2015, we recruited 6495 inpatients with GI cancers in a tertiary hospital in eastern China. Data on demographics, clinical and laboratory indicators were retrospectively extracted from the electronic medical record system. Predictors of AKI were selected in gLASSO regression, and further incorporated into BNs analysis.

resultsThe incidences of AKI in patients with esophagus, stomach, and intestine cancer were 20.5%, 13.9%, and 12.5%, respectively. Through gLASSO, 11 predictors were screened out, including diabetes, cancer category, anti-tumor treatment, ALT, serum creatinine, estimated glomerular filtration rate (eGFR), serum uric acid (SUA), hypoalbuminemia, anemia, abnormal sodium, and potassium. BNs model revealed that cancer category, treatment, eGFR, and hypoalbuminemia had direct connections with AKI. Diabetes and SUA were indirectly linked to AKI through eGFR, and anemia created connections with AKI through affecting album level. Compared with other ML models, BNs model maintained a higher AUC value in both the internal and external validation (AUC: 0.823/0.790).

conclusionBNs model not only delineates the qualitative and quantitative relationship between AKI and its associated factors but shows the more robust generalizability in AKI prediction.

Indexed as

Health Status IndicatorsAcute Kidney InjuryAgedBayes TheoremChinaFemaleGastrointestinal NeoplasmsHumansIncidenceInpatientsMaleMiddle AgedPredictive Value of TestsRegression AnalysisRetrospective StudiesRisk Assessmentacute kidney injuryBayesian networkdisease predictionGastrointestinal cancerGroup LASSOmachine learning

Identifiers

PMID32838613
PMCPMC7472473
OpenAlexW3080875344

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.