Evidence map›Paper›PMID 32841759›Full record

ArticleVirology2020

The splice 1 variant of HTLV-1 bZIP factor stabilizes c-Jun.

Nicholas Polakowski, Martin Pearce, Oppah Kuguyo, Georgina Boateng, Kimson Hoang, Isabelle Lemasson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Upregulation of Neuropilin-1 Inhibits HTLV-1 Infection.Pathogens (Basel, Switzerland) · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nicholas PolakowskiECU, Brody School of Medicine, Department of Microbiology and Immunology, Greenville, NC, 27834, USA. Electronic address: polakowskin@ecu.edu.
Martin PearceECU, Brody School of Medicine, Department of Microbiology and Immunology, Greenville, NC, 27834, USA.
Oppah KuguyoECU, Brody School of Medicine, Department of Microbiology and Immunology, Greenville, NC, 27834, USA.
Georgina BoatengECU, Brody School of Medicine, Department of Microbiology and Immunology, Greenville, NC, 27834, USA.
Kimson HoangECU, Brody School of Medicine, Department of Microbiology and Immunology, Greenville, NC, 27834, USA.
Isabelle LemassonECU, Brody School of Medicine, Department of Microbiology and Immunology, Greenville, NC, 27834, USA. Electronic address: lemassoni@ecu.edu.
East Carolina University · US

Funding

Regulation of HTLV-1 and cellular gene transcription by the viral protein HBZR01CA128800 · NCI · EAST CAROLINA UNIVERSITY · PI LEMASSON, ISABELLE MICHELE · 2010 to 2014
$1.3M
Activation of HMOX1 expression by an HBZ-small Maf complex as a potential therapeutic target for HTLV-1 associated diseases.R21AI133163 · NIAID · EAST CAROLINA UNIVERSITY · PI LEMASSON, ISABELLE MICHELE · 2018 to 2019
$406k
NCI NIH HHS R01 CA128800NIAID NIH HHS R21 AI133163
6 · The paper itself

Abstract

HBZ is expressed by the complex retrovirus, Human T-cell Leukemia Virus type 1, and implicated in pathological effects associated with viral infection. From the nucleus, HBZ alters gene expression by interacting with a variety of transcriptional regulatory proteins, among which is c-Jun. Previously, one of the three HBZ variants, HBZ

Indexed as

Alternative SplicingBasic-Leucine Zipper Transcription FactorsCarrier ProteinsCell LineCell NucleusCullin ProteinsDNA-Binding ProteinsHEK293 CellsHeLa CellsHost-Pathogen InteractionsHumansHuman T-lymphotropic virus 1JNK Mitogen-Activated Protein KinasesJurkat CellsPrimary Cell CultureProtein BindingBasic-Leucine Zipper Transcription FactorsCarrier ProteinsCOP1 protein, humanCUL4A protein, humanCullin ProteinsDDB1 protein, humanDET1 protein, humanDNA-Binding ProteinsHBZ protein, human T-cell leukemia virus type IJNK Mitogen-Activated Protein KinasesRBX1 protein, humanRetroviridae ProteinsUbiquitin-Protein Ligasesc-JunCop1HBZ splice 1 variantHTLV-1

Identifiers

PMID32841759
PMCPMC7528937
OpenAlexW3047949039

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.