Evidence map›Paper›PMID 32842549›Full record

ReviewInternational journal of molecular sciences2020

The Endosomal Recycling Pathway-At the Crossroads of the Cell.

Mary J O'Sullivan, Andrew J Lindsay

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

  1. Article
  2. Review
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  9. Review
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  15. Article
  16. Review
  17. The strategies and advances of mRNA translation booster.Asian journal of pharmaceutical sciences · 2025
    Review
  18. Endosomal Mechanisms in Heart Failure Pathophysiology.Current heart failure reports · 2025
    Review
  19. Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mary J O'SullivanMembrane Trafficking and Disease Laboratory, School of Biochemistry & Cell Biology, Biosciences Institute, University College Cork, T12 YT20 Cork, Ireland.
Andrew J LindsayMembrane Trafficking and Disease Laboratory, School of Biochemistry & Cell Biology, Biosciences Institute, University College Cork, T12 YT20 Cork, Ireland.ORCID 0000-0001-9693-7022

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The endosomal recycling pathway lies at the heart of the membrane trafficking machinery in the cell. It plays a central role in determining the composition of the plasma membrane and is thus critical for normal cellular homeostasis. However, defective endosomal recycling has been linked to a wide range of diseases, including cancer and some of the most common neurological disorders. It is also frequently subverted by many diverse human pathogens in order to successfully infect cells. Despite its importance, endosomal recycling remains relatively understudied in comparison to the endocytic and secretory transport pathways. A greater understanding of the molecular mechanisms that support transport through the endosomal recycling pathway will provide deeper insights into the pathophysiology of disease and will likely identify new approaches for their detection and treatment. This review will provide an overview of the normal physiological role of the endosomal recycling pathway, describe the consequences when it malfunctions, and discuss potential strategies for modulating its activity.

Indexed as

Alzheimer DiseaseDrug Delivery SystemsEndocytosisEndosomesHumansMalabsorption SyndromesMicrovilliMucolipidosesNeoplasmsParkinson DiseaseProtein Transportrab GTP-Binding ProteinsSecretory PathwaySmall Molecule Librariesrab GTP-Binding ProteinsSmall Molecule Librariescancerendosomal recycling pathwayneurological disorderspathogen infectionplasma membraneRab GTPasessmall molecule inhibitorsvesicle trafficking

Identifiers

PMID32842549
PMCPMC7503921

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.