Evidence mapPaperPMID 32844500Full record

ReviewMagnetic resonance in medicine2021

Quantitative

Pernilla Peterson, Lena Trinh, Sven Månsson

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07178145 (MRI of Epicardial Adipose Tissue Composition), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07178145 phase4recruitingstarted 2025, after this paper: background citation

MRI of Epicardial Adipose Tissue Composition: Development of Methods and Application to Heart Failure With Preserved Ejection Fraction

Ran2025Enrolled192Registered outcomes6Posted comparisons0ConditionsEpicardial Adipose Tissue, Heart Failure Preserved Ejection FractionArmsGLP-1RA
Open the trial in the graph
3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. MR spectroscopy in differentiating spinal atypical hemangioma from metastasis: preliminary results.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  6. Poor muscle quality: A hidden and detrimental health condition in obesity.Reviews in endocrine & metabolic disorders · 2025
    Review
  7. Article
  8. Compositional and Functional MRI of Skeletal Muscle: A Review.Journal of magnetic resonance imaging : JMRI · 2024
    Review
  9. Free-breathing MRI techniques for fat and RMagma (New York, N.Y.) · 2024
    Review
  10. Aliphatic and Olefinic Fat Suppression in the Orbit Using Polarity-altered Spectral and Spatial Selective Acquisition (PASTA) with Opposed Phase.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024
    Article
  11. Magnetic resonance spectroscopy (MRS) of multifidus muscle metabolites in chronic low back pain (CLBP).European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023
    Article
  12. Magnetic resonance spectroscopy (MRS) of multifidus muscle metabolites in chronic low back pain (CLBP).European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pernilla PetersonMedical Radiation Physics, Malmö, Department of Translational Medicine, Lund University, Skåne University Hospital, Malmö, Sweden.ORCID 0000-0002-7533-8503
Lena TrinhMedical Radiation Physics, Malmö, Department of Translational Medicine, Lund University, Skåne University Hospital, Malmö, Sweden.ORCID 0000-0002-9843-5381
Sven MånssonMedical Radiation Physics, Malmö, Department of Translational Medicine, Lund University, Skåne University Hospital, Malmö, Sweden.ORCID 0000-0002-5706-5142

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose tissue as well as other depots of fat (triglycerides) are increasingly being recognized as active contributors to the human function and metabolism. In addition to the fat concentration, also the fatty acid chemical composition (FAC) of the triglyceride molecules may play an important part in diseases such as obesity, insulin resistance, hepatic steatosis, osteoporosis, and cancer. MR spectroscopy and chemical-shift-encoded imaging (CSE-MRI) are established methods for non-invasive quantification of fat concentration in tissue. More recently, similar techniques have been developed for assessment also of the FAC in terms of the number of double bonds, the fraction of saturated, monounsaturated, and polyunsaturated fatty acids, or semi-quantitative unsaturation indices. The number of papers focusing on especially CSE-MRI-based techniques has steadily increased during the past few years, introducing a range of acquisition protocols and reconstruction algorithms. However, a number of potential sources of bias have also been identified. Furthermore, the measures used to characterize the FAC using both MRI and MRS differ, making comparisons between different techniques difficult. The aim of this paper is to review MRS- and MRI-based methods for in vivo quantification of the FAC. We describe the chemical composition of triglycerides and discuss various potential FAC measures. Furthermore, we review acquisition and reconstruction methodology and finally, some existing and potential applications are summarized. We conclude that both MRI and MRS provide feasible non-invasive alternatives to the gold standard gas chromatography for in vivo measurements of the FAC. Although both are associated with gas chromatography, future studies are warranted.

Indexed as

Fatty AcidsMagnetic Resonance ImagingAdipose TissueHumansLiverMagnetic Resonance SpectroscopyProspective StudiesReproducibility of ResultsFatty AcidsCSE-MRIfatty acid compositionfat unsaturationMRIMRS

Identifiers

PMID32844500

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.