Evidence map›Paper›PMID 32847853›Full record

ArticleJournal of virology2020

Epstein-Barr Virus gH/gL and Kaposi's Sarcoma-Associated Herpesvirus gH/gL Bind to Different Sites on EphA2 To Trigger Fusion.

Jia Chen, Samantha Schaller, Theodore S Jardetzky, Richard Longnecker

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

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  15. PIPThe Journal of biological chemistry
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jia ChenDepartment of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Samantha SchallerDepartment of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Theodore S JardetzkyDepartment of Structural Biology, Stanford University School of Medicine, Stanford, California, USA.
Richard LongneckerDepartment of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA r-longnecker@northwestern.edu.ORCID 0000-0001-7175-6217
Northwestern University · USStanford University · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9M
Structural and Functional Studies of gp42 and HLA Class II in EBV EntryR01AI076183 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI JARDETZKY, THEODORE S, LONGNECKER, RICHARD M · 2008 to 2017
$4.6M
Structure and Function of EBV Protein Complexes that Trigger Epithelial Cell EntryR01AI137267 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI JARDETZKY, THEODORE S, LONGNECKER, RICHARD M · 2018 to 2022
$3.6M
Functional Studies of gp42 and HLA Class 11 in EBVR01CA093444 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LONGNECKER, RICHARD M · 2002 to 2006
$1.8M
NCI NIH HHS P30 CA060553NCI NIH HHS R01 CA093444NIAID NIH HHS R01 AI076183NIAID NIH HHS R01 AI137267
6 · The paper itself

Abstract

Both Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) are human gammaherpesviruses and are important in a variety of malignancies. Eph family receptor tyrosine kinase A2 (EphA2) is a cellular receptor for KSHV and EBV. Previous studies identified five conserved residues (ELEFN

Indexed as

Amino Acid MotifsAmino Acid SequenceAnimalsBinding SitesCHO CellsCricetulusEphrin-A2Gene Expression RegulationGlycosylationHEK293 CellsHerpesvirus 4, HumanHerpesvirus 8, HumanHost-Pathogen InteractionsHumansMembrane GlycoproteinsModels, MolecularEPHA2 protein, humanEphrin-A2glycoprotein H, Herpesvirus 4glycoprotein L, Human herpesvirus 4Membrane GlycoproteinsMolecular ChaperonesProtein IsoformsReceptor, EphA2Receptors, VirusViral Envelope ProteinsViral ProteinsEPH receptorsEpstein-Barr virusherpesvirusesKaposi’s sarcoma-associated herpesvirusvirus entry

Identifiers

PMID32847853
PMCPMC7565624
OpenAlexW3081504053

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.