ReviewFrontiers in chemistry2020
2H/4H-Chromenes-A Versatile Biologically Attractive Scaffold.
Review in Frontiers in chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- 4H-CRCXL Mitigates RasV12-Induced Phenotypes in Glioblastoma Model of Drosophila.Molecular carcinogenesis · 2026Article
- New Chromene Derivatives as Promising VEGFR-2 Inhibitors: Experimental Cytotoxicity and Comprehensive Computational Characterization.Archiv der Pharmazie · 2026Article
- Bifunctional recyclable ZnO/MgO nanocomposite: solvent-free synthesis of chromenes and efficient water remediation.Scientific reports · 2026Article
- New benzochromene-based compounds as potential EGFR-TK inhibitors: synthesis, anti-proliferative activity, molecular docking studies, and ADME profiles.RSC advances · 2026Article
- Discovery of thieno[3,2-RSC advances · 2026Article
- l-Arg@ZY-FeNanoscale advances · 2026Article
- Structure, biological activity, and biosynthesis of natural chromanes and chromenes.Archives of pharmacal research · 2025Review
- A novel chromen-based small molecule induces apoptosis and modulates cellular response to triple-negative breast cancer.Scientific reports · 2025Article
- A novel nanocatalyst praseodymium oxide (PrRSC advances · 2025Article
- Visible-Light Photocatalysis for Sustainable Chromene Synthesis and Functionalization.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- Regulation of adipocyte differentiation and lipid metabolism by novel synthetic chromenes exploring anti-obesity and broader therapeutic potential.Scientific reports · 2025Article
- Development of novel 9H-carbazole-4H-chromene hybrids as dual cholinesterase inhibitors for the treatment of Alzheimer's disease.Molecular diversity · 2025Article
- Synthesis of Chromene-linked Bis-indole Derivatives as Selective Tumor-associated Carbonic Anhydrase IX Inhibitors.Anti-cancer agents in medicinal chemistry · 2025Article
- TiORSC advances · 2024Article
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- Article
- How Can Deep Eutectic Systems Promote Greener Processes in Medicinal Chemistry and Drug Discovery?Pharmaceuticals (Basel, Switzerland) · 2024Review
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- Synthesis of 4-aryl-3,4-dihydrocoumarins and 4-aryl-4RSC advances · 2023Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
2H/4H-chromene (2H/4H-ch) is an important class of heterocyclic compounds with versatile biological profiles, a simple structure, and mild adverse effects. Researchers discovered several routes for the synthesis of a variety of 2H/4H-ch analogs that exhibited unusual activities by multiple mechanisms. The direct assessment of activities with the parent 2H/4H-ch derivative enables an orderly analysis of the structure-activity relationship (SAR) among the series. Additionally, 2H/4H-ch have numerous exciting biological activities, such as anticancer, anticonvulsant, antimicrobial, anticholinesterase, antituberculosis, and antidiabetic activities. This review is consequently an endeavor to highlight the diverse synthetic strategies, synthetic mechanism, various biological profiles, and SARs regarding the bioactive heterocycle, 2H/4H-ch. The presented scaffold work compiled in this article will be helpful to the scientific community for designing and developing potent leads of 2H/4H-ch analogs for their promising biological activities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.