Evidence map›Paper›PMID 32851082›Full record

ArticleBioMed research international2020

Rapamycin Inhibited Pyroptosis and Reduced the Release of IL-1

Luo Zhuo, Xiaobing Chen, Yan Sun, Yanli Wang, Yuanfeng Shi, Lin Bu, Wei Xia, Jiayan Han, Dongmei Chen, Xiaomin Li

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Regulation of alveolar macrophage death in pulmonary fibrosis: a review.Apoptosis : an international journal on programmed cell death · 2023
    Review
  6. Pyroptosis and airway homeostasis regulation.Physiological research · 2023
    Review
  7. The Interplay Between Autophagy and Regulated Necrosis.Antioxidants & redox signaling · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Electroacupuncture at ST36 (Journal of inflammation research · 2022
    Article
  13. Review
  14. Review
  15. Role of adiponectin in osteoarthritis.Frontiers in cell and developmental biology · 2022
    Review
  16. Gasdermins in Innate Host Defense AgainstFrontiers in immunology · 2022
    Review
  17. Article
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Luo ZhuoDepartment of Emergency Medicine, The Affiliated Lianyungang Hospital of Xuzhou Medical University, No. 182 North Tongguan Road, Lianyungang 222002, China.ORCID https://orcid.org/0000-0003-2394-5712
Xiaobing ChenDepartment of Emergency Medicine, The Affiliated Lianyungang Hospital of Xuzhou Medical University, No. 182 North Tongguan Road, Lianyungang 222002, China.
Yan SunDepartment of Emergency Medicine, The Clinical Medical School of Nanjing Medical University Affiliated Hospital of Lianyungang First People's Hospital, No. 182 North Tongguan Road, Lianyungang 222002, China.
Yanli WangDepartment of Emergency Medicine, The Affiliated Lianyungang Hospital of Xuzhou Medical University, No. 182 North Tongguan Road, Lianyungang 222002, China.
Yuanfeng ShiDepartment of Emergency Medicine, The Affiliated Lianyungang Hospital of Xuzhou Medical University, No. 182 North Tongguan Road, Lianyungang 222002, China.
Lin BuDepartment of Critical Care Medicine, Xuzhou Medical University Affiliated Hospital, No. 99 West Huaihai Road, Xuzhou 221000, China.
Wei XiaDepartment of Intensive Care Unit, The Affiliated Wuxi People's Hospital of Nanjing Medical University, No. 299 Qingyang Road, Wuxi 214000, China.
Jiayan HanDepartment of Emergency Medicine, The Clinical Medical School of Nanjing Medical University Affiliated Hospital of Lianyungang First People's Hospital, No. 182 North Tongguan Road, Lianyungang 222002, China.
Dongmei ChenDepartment of Emergency Medicine, The Affiliated Lianyungang Hospital of Xuzhou Medical University, No. 182 North Tongguan Road, Lianyungang 222002, China.
Xiaomin LiDepartment of Emergency Medicine, The Affiliated Lianyungang Hospital of Xuzhou Medical University, No. 182 North Tongguan Road, Lianyungang 222002, China.ORCID https://orcid.org/0000-0002-8494-7132
Xuzhou Medical College · CNThe First People’s Hospital of Lianyungang · CNWuxi People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyroptosis, an inflammatory form of programmed cell death, is the initiating event of sepsis and results in immune imbalance by releasing IL-1

Indexed as

AutophagyCaspase 1GasderminsGene Expression RegulationHumansHuman Umbilical Vein Endothelial CellsInterleukin-18Interleukin-1betaIntracellular Signaling Peptides and ProteinsLipopolysaccharidesMacrophagesPhosphate-Binding ProteinsPyroptosisSepsisSirolimusTHP-1 CellsCaspase 1GasderminsGSDMD protein, humanIL1B protein, humanInterleukin-18Interleukin-1betaIntracellular Signaling Peptides and ProteinsLipopolysaccharidesPhosphate-Binding ProteinsSirolimus

Identifiers

PMID32851082
PMCPMC7436330
OpenAlexW3048020531

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.