Evidence map›Paper›PMID 32851660›Full record

ArticleInternational journal of cancer2021

Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer.

Pik-Fang Kho, Frederic Amant, Daniela Annibali, Katie Ashton, John Attia, Paul L Auer, Matthias W Beckmann, Amanda Black, Louise Brinton, Daniel D Buchanan and 84 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Observational
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  9. Understanding risk factors for endometrial cancer in young women.Journal of the National Cancer Institute · 2025
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  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

94 authors at 20 institutions in 11 countries.

Pik-Fang KhoDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Frederic AmantDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals KU Leuven, University of Leuven, Leuven, Belgium.
Daniela AnnibaliDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals KU Leuven, University of Leuven, Leuven, Belgium.
Katie AshtonHunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia.
John AttiaHunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia.
Paul L AuerCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Matthias W BeckmannDepartment of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
Amanda BlackDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Louise BrintonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Daniel D BuchananDepartment of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0003-2225-6675
Stephen J ChanockDepartment of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Chu ChenEpidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.ORCID 0000-0003-2267-8050
Maxine M ChenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Timothy H T ChengWellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Linda S CookUniversity of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Marta Crous-BousDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Immaculata De VivoDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-7185-7402
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Thilo DörkGynaecology Research Unit, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-9458-0282
Sean C DowdyDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mayo Clinic, Rochester, Minnesota, USA.
Alison M DunningCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Matthias DürstDepartment of Gynaecology, Jena University Hospital - Friedrich Schiller University, Jena, Germany.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Arif B EkiciInstitute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
Peter A FaschingDepartment of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.ORCID 0000-0003-4885-8471
Brooke L FridleyDepartment of Biostatistics, Kansas University Medical Center, Kansas City, Kansas, USA.
Christine M FriedenreichDepartment of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, Alberta, Canada.ORCID 0000-0002-4783-1966
Montserrat García-ClosasDepartment of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Mia M GaudetBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia, USA.ORCID 0000-0002-6429-4007
Graham G GilesCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Ellen L GoodeDepartment of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-9094-8326
Maggie GormanWellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Susan E HankinsonChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Alexander HeinDepartment of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
Peter HillemannsGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Shirley HodgsonDepartment of Clinical Genetics, St George's, University of London, London, UK.
Erling A HoivikCentre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.
Elizabeth G HollidayHunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia.
David J HunterDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Angela JonesWellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Peter KraftDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Camilla KrakstadCentre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.
Diether LambrechtsVIB Center for Cancer Biology, Leuven, Belgium.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Xiaolin LiangDepartment of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Jolanta LissowskaDepartment of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Cancer Center, Oncology Institute, Warsaw, Poland.
Jirong LongDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Lingeng LuChronic Disease Epidemiology, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0001-9871-0809
Anthony M MaglioccoDepartment of Anatomic Pathology, Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.
Lynn MartinInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Mark McEvoyCentre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.
Roger L MilneCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Miriam MintsDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Rami NassirDepartment of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, USA.
Geoffrey OttonSchool of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.
Claire PallesWellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Loreall PoolerDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Tony ProiettoSchool of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.
Timothy R RebbeckHarvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Stefan P RennerDepartment of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
Harvey A RischChronic Disease Epidemiology, Yale School of Medicine, New Haven, Connecticut, USA.
Matthias RübnerDepartment of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
Ingo RunnebaumDepartment of Gynaecology, Jena University Hospital - Friedrich Schiller University, Jena, Germany.
Carlotta SacerdoteCenter for Cancer Prevention (CPO-Peimonte), Turin, Italy.ORCID 0000-0002-8008-5096
Gloria E SartoDepartment of Obstetrics and Gynecology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.
Fredrick SchumacherDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Rodney J ScottHunter Medical Research Institute, John Hunter Hospital, Newcastle, New South Wales, Australia.
V Wendy SetiawanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Mitul ShahCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Xin ShengDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0002-0711-8314
Melissa C SoutheyDepartment of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia.
Emma ThamDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Ian TomlinsonWellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Jone TrovikCentre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.
Constance TurmanDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Jonathan P TyrerCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
David Van Den BergDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Zhaoming WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.ORCID 0000-0001-7556-3869
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.ORCID 0000-0003-1251-0836
Lucy XiaDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Yong-Bing XiangState Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.ORCID 0000-0002-3840-9915
Hannah P YangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Herbert YuEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.ORCID 0000-0003-3950-4815
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Penelope M WebbPopulation Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Deborah J ThompsonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Amanda B SpurdleDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0003-1337-7897
Dylan M GlubbDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Tracy A O'MaraDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0002-5436-3232
University of Cambridge · GBUniversity of Southern California · USCentre for Human Genetics · GBHarvard University · USNational Cancer Institute · USUniversitätsklinikum Erlangen · DEJohn Hunter Hospital · AUKarolinska Institutet · SEQIMR Berghofer Medical Research Institute · AUBrigham and Women's Hospital · USHaukeland University Hospital · NOThe University of Melbourne · AUUniversity of Newcastle Australia · AUVanderbilt University · USAlberta Health Services · CAJena University Hospital · DEKU Leuven · BEMayo Clinic · USMedizinische Hochschule Hannover · DENational Institutes of Health · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI FRANCESCA M GANY · 1985 to 2026
$347.4M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI CHERYL LYNN WILLMAN · 1985 to 2026
$151.3M
Hormone-Related CancersZIACP010126 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$103.5M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI Zhenkun Lou · 2009 to 2026
$37.0M
CALIFORNIA TEACHERS STUDYR01CA077398 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERNSTEIN, LESLIE · 1998 to 2014
$29.7M
Multiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
USC CANCER EPIDEMIOLOGY &BIOSTATISTICS UNITP01CA017054 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PIKE, MALCOLM C · 1985 to 2009
$18.2M
BIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3M
Epidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6M
Cancer Research UK 16563Cancer Research UK 16565Cancer Research UK 29186Cancer Research UK C12292/A11174Cancer Research UK C1281/A12014Cancer Research UK C1287/A10118Cancer Research UK C1287/A10710Cancer Research UK C490/A10124Cancer Research UK C5047/A10692Cancer Research UK C5047/A15007Cancer Research UK C5047/A8384Cancer Research UK C8197/A16565NCATS NIH HHS UL1 TR001863NCI NIH HHS K05 CA092002NCI NIH HHS K05 CA136967NCI NIH HHS P01 CA017054NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA015083NCI NIH HHS P50 CA136393NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA058598NCI NIH HHS R01 CA074847NCI NIH HHS R01 CA077398NCI NIH HHS R01 CA082838NCI NIH HHS R01 CA087538NCI NIH HHS R01 CA091019NCI NIH HHS R01 CA098346NCI NIH HHS R01 CA105212NCI NIH HHS R01 CA108634NCI NIH HHS R01 CA122443NCI NIH HHS R01 CA128978NCI NIH HHS R01 CA134958NCI NIH HHS R01 CA149429NCI NIH HHS R03 CA080636NCI NIH HHS R03 CA096400NCI NIH HHS R03 CA128008NCI NIH HHS R37 CA054281NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148065-01NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148537NCI NIH HHS UM1 CA186107NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CNICHD NIH HHS N01 HD023166NIH HHS CA128978Wellcome TrustWellcome Trust 068545/Z/02Wellcome Trust 085475Wellcome Trust 090532/Z/09ZWellcome Trust 100069Wellcome Trust 209057WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

Blood lipids have been associated with the development of a range of cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies have reported inconsistent associations between blood lipids and cancer risk. To reduce biases from unmeasured confounding, we performed a bidirectional, two-sample Mendelian randomization analysis to investigate the relationship between levels of three blood lipids (low-density lipoprotein [LDL] and high-density lipoprotein [HDL] cholesterol, and triglycerides) and endometrial cancer risk. Genetic variants associated with each of these blood lipid levels (P < 5 × 10

Indexed as

Case-Control StudiesCholesterol, HDLCholesterol, LDLEndometrial NeoplasmsFemaleGenome-Wide Association StudyHumansMendelian Randomization AnalysisRiskTriglyceridesCholesterol, HDLCholesterol, LDLTriglyceridesendometrial cancer riskHDL cholesterolLDL cholesterolMendelian randomizationtriglycerides

Identifiers

PMID32851660
PMCPMC7757859
OpenAlexW3042240604

What Socratic holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.