Evidence map›Paper›PMID 32854610›Full record

ArticleGenes & nutrition2020

Low-grade chronic inflammation is attenuated by exercise training in obese adults through down-regulation of ASC gene in peripheral blood: a pilot study.

Elisa Barrón-Cabrera, Karina González-Becerra, Gustavo Rosales-Chávez, Alondra Mora-Jiménez, Iván Hernández-Cañaveral, Erika Martínez-López

3 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04315376 nacompletednot on this map

Exercise Program and Diet Intervention Attenuated Inflammation Through Down-regulation of ASC Gene and Inflammatory Markers in Obese Adults

TypeinterventionalSponsorUniversity of GuadalajaraRan2018 to 2019Enrolled37ConditionsInflammatory Response, Obesity, Abdominal Obesity, Diet HabitArmsExercise-Diet Intervention, Diet Intervention
NCT05482178 naunknown statusnot on this mapstarted 2022, after this paper: background citation

The Potential Role of Resistance Exercise on Inflammasome Activation and Cytokines Levels in Obese Subjects

TypeinterventionalSponsorElisa Barron-CabreraRan2022 to 2022Enrolled20ConditionsPhysical Activity, Resistance Exercise, Inflammation, ObesityArmsResistance exercise training plus hypocaloric diet, Hypocaloric diet
NCT05700292 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of High-intensity Interval Training on Low-grade Systemic Inflammation in Obese Young Adults

TypeinterventionalSponsorUniversity of GuadalajaraRan2023 to 2023Enrolled32ConditionsObesityArmsHigh-intensity Interval Training, Moderate-intensity continuous training
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Plant-DerivedNutrients · 2022
    Trial
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Pharmacological targeting of adaptor proteins in chronic inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. NLRP3 Inflammasome in Diabetic Cardiomyopathy and Exercise Intervention.International journal of molecular sciences · 2021
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Elisa Barrón-CabreraInstitute of Translational Nutrigenetics and Nutrigenomics, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Sierra Mojada 950, zip code, 44340, Guadalajara, Jalisco, México.
Karina González-BecerraInstitute of Translational Nutrigenetics and Nutrigenomics, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Sierra Mojada 950, zip code, 44340, Guadalajara, Jalisco, México.
Gustavo Rosales-ChávezRespiratory Therapy Unit, Health Sciences University Center, University of Guadalajara, Sierra Mojada 950, zip code, 44340, Guadalajara, Jalisco, México.
Alondra Mora-JiménezInstitute of Translational Nutrigenetics and Nutrigenomics, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Sierra Mojada 950, zip code, 44340, Guadalajara, Jalisco, México.
Iván Hernández-CañaveralMicrobiology and Pathology Department, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Sierra Mojada 950, zip code, 44340, Guadalajara, Jalisco, México.
Erika Martínez-LópezInstitute of Translational Nutrigenetics and Nutrigenomics, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Sierra Mojada 950, zip code, 44340, Guadalajara, Jalisco, México. erikamtz27@yahoo.com.mx.ORCID http://orcid.org/0000-0003-2005-9512
Universidad de Guadalajara · MX

Funding

Consejo Nacional de Ciencia y Tecnología 202540
6 · The paper itself

Abstract

backgroundObesity is characterized by low-grade chronic inflammation and an excess of adipose tissue. The ASC gene encodes a protein that is part of the NLRP3 inflammasome, a cytosolic multiprotein complex that is associated with inflammation and metabolic alterations. To our knowledge, there is no evidence regarding ASC gene activity in obese adults in response to lifestyle modifications. PURPOSE: To evaluate the effect of hypocaloric diet and moderate-intensity structured exercise intervention on ASC gene expression and inflammatory markers in obese adults.

methodsThirty-seven obese individuals aged 25 to 50 years were randomized to the hypocaloric diet exercise group or hypocaloric diet group. The participants underwent a 4-month follow-up. Electrical bioimpedance was used for body composition analysis. Biochemical data were analyzed by dry chemistry and insulin levels by ELISA. ASC gene expression from peripheral blood was performed using real-time PCR. Dietary data was collected through questionnaires and analyzed using the Nutritionist Pro™ software. Quantification of cytokines was conducted using Bio-Plex Pro™ Human cytokine. The Astrand-Ryhming test was used to estimate the maximum oxygen volume and design the moderate-intensity structured exercise program ~ 75% heart rate (HR)

resultsAfter the intervention, both study groups significantly improved body composition (decreased weight, fat mass, waist circumference and abdominal obesity, p < 0.05). Besides, the diet-exercise group significantly decreased ASC mRNA expression, MCP-1, and MIP-1β inflammatory cytokines compared to the diet group (p < 0.05). While in the diet group, MCP-1 and IL-8 exhibited significantly decreased levels (p < 0.05). In the diet-exercise group, a positive correlation between the atherogenic index and waist circumference was found (r = 0.822, p = 0.011), and a negative correlation was observed between the delta of ASC mRNA expression and IL-10 levels at the end of the intervention (r = - 0.627, p = 0.019).

conclusionLow-grade chronic inflammation was attenuated through individualized exercise prescription and our findings highlight the role of the ASC gene in the inflammation of obese adults.

trial registrationClinicalTrials.gov , number NCT04315376 . Registered 20 March 2020-retrospectively registered.

Indexed as

DietExerciseInflammationNutrition

Identifiers

PMID32854610
PMCPMC7457251
OpenAlexW3081179084

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.