Evidence map›Paper›PMID 32855222›Full record

ArticleThe European respiratory journal2021

Ivacaftor modifies cystic fibrosis neutrophil phenotype in subjects with R117H residual function CFTR mutations.

Gareth R Hardisty, Sheonagh M Law, Suzanne Carter, Brenda Grogan, Pradeep K Singh, Edward F McKone, Robert D Gray

Open access · hybridAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in The European respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. The Effect of CFTR Modulators on Airway Infection in Cystic Fibrosis.International journal of molecular sciences · 2022
    Review
  6. Mucosal Immunity in Cystic Fibrosis.Journal of immunology (Baltimore, Md. : 1950) · 2021
    Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Gareth R HardistyUniversity of Edinburgh, Centre for Inflammation Research, Edinburgh, UK.
Sheonagh M LawUniversity of Edinburgh, Centre for Inflammation Research, Edinburgh, UK.
Suzanne CarterSt Vincent's Hospital, University College Dublin, Dublin, Ireland.
Brenda GroganSt Vincent's Hospital, University College Dublin, Dublin, Ireland.
Pradeep K SinghDept of Microbiology, University of Washington School of Medicine, Seattle, WA, USA.
Edward F McKoneSt Vincent's Hospital, University College Dublin, Dublin, Ireland.
Robert D GrayUniversity of Edinburgh, Centre for Inflammation Research, Edinburgh, UK r.d.gray@ed.ac.uk.ORCID 0000-0002-2203-2703
Centre for Inflammation Research · GBUniversity College Dublin · IEUniversity of Washington · US

Funding

Studies on bacterial populations and therapeutics for CF lung infectionsK24HL102246 · NHLBI · UNIVERSITY OF WASHINGTON · PI SINGH, PRADEEP K · 2010 to 2019
$1.6M
Chief Scientist Office SCAF/16/02NHLBI NIH HHS K24 HL102246Wellcome Trust 093767/Z/10/ZWellcome Trust 201246/Z/16/Z
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cystic FibrosisAminophenolsCystic Fibrosis Transmembrane Conductance RegulatorHumansMutationNeutrophilsPhenotypeQuinolonesAminophenolsCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorivacaftorQuinolones

Identifiers

PMID32855222
PMCPMC7817919
OpenAlexW3080654240

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.